以金纳米颗粒及其聚集体作为散射造影剂的流式细胞术：光与细胞相互作用的时域有限差分模拟
Flow cytometry with gold nanoparticles and their clusters as scattering contrast agents: FDTD simulation of light-cell interaction.
作者信息
Tanev Stoyan, Sun Wenbo, Pond James, Tuchin Valery V, Zharov Vladimir P
机构信息
Technology Innovation Management Program in the Department of Systems and Computer Engineering, Faculty of Engineering and Design, Carleton University, Ottawa, ON, Canada.
出版信息
J Biophotonics. 2009 Sep;2(8-9):505-20. doi: 10.1002/jbio.200910039.
Abstract
The formulation of the finite-difference time-domain (FDTD) approach is presented in the framework of its potential applications to in-vivo flow cytometry based on light scattering. The consideration is focused on comparison of light scattering by a single biological cell alone in controlled refractive-index matching conditions and by cells labeled by gold nanoparticles. The optical schematics including phase contrast (OPCM) microscopy as a prospective modality for in-vivo flow cytometry is also analyzed. The validation of the FDTD approach for the simulation of flow cytometry may open up a new avenue in the development of advanced cytometric techniques based on scattering effects from nanoscale targets.
摘要
本文在基于光散射的体内流式细胞术潜在应用框架下，介绍了时域有限差分（FDTD）方法的公式。重点考虑了在可控折射率匹配条件下单个生物细胞的光散射与金纳米颗粒标记细胞的光散射的比较。还分析了包括相衬显微镜（OPCM）作为体内流式细胞术潜在模式的光学原理图。FDTD方法用于流式细胞术模拟的验证，可能为基于纳米级目标散射效应的先进细胞术技术发展开辟一条新途径。
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