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Finite-difference time-domain solution of light scattering by dielectric particles with a perfectly matched layer absorbing boundary condition.采用完全匹配层吸收边界条件的介质粒子光散射的时域有限差分法求解
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Optical detection of intracellular cavitation during selective laser targeting of the retinal pigment epithelium: dependence of cell death mechanism on pulse duration.视网膜色素上皮细胞选择性激光靶向过程中细胞内空化的光学检测：细胞死亡机制对脉冲持续时间的依赖性。
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9
Self-assembling nanoclusters in living systems: application for integrated photothermal nanodiagnostics and nanotherapy.生物系统中的自组装纳米团簇：在集成光热纳米诊断与纳米治疗中的应用。
Nanomedicine. 2005 Dec;1(4):326-45. doi: 10.1016/j.nano.2005.10.006.
10
Cell membrane and gold nanoparticles effects on optical immersion experiments with noncancerous and cancerous cells: finite-difference time-domain modeling.细胞膜和金纳米颗粒对非癌细胞和癌细胞光学浸入实验的影响：时域有限差分建模
J Biomed Opt. 2006 Nov-Dec;11(6):064037. doi: 10.1117/1.2400239.

以金纳米颗粒及其聚集体作为散射造影剂的流式细胞术：光与细胞相互作用的时域有限差分模拟

Flow cytometry with gold nanoparticles and their clusters as scattering contrast agents: FDTD simulation of light-cell interaction.

作者信息

Tanev Stoyan, Sun Wenbo, Pond James, Tuchin Valery V, Zharov Vladimir P

机构信息

Technology Innovation Management Program in the Department of Systems and Computer Engineering, Faculty of Engineering and Design, Carleton University, Ottawa, ON, Canada.

出版信息

J Biophotonics. 2009 Sep;2(8-9):505-20. doi: 10.1002/jbio.200910039.

DOI:10.1002/jbio.200910039
PMID:19670359
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2893151/
Abstract

The formulation of the finite-difference time-domain (FDTD) approach is presented in the framework of its potential applications to in-vivo flow cytometry based on light scattering. The consideration is focused on comparison of light scattering by a single biological cell alone in controlled refractive-index matching conditions and by cells labeled by gold nanoparticles. The optical schematics including phase contrast (OPCM) microscopy as a prospective modality for in-vivo flow cytometry is also analyzed. The validation of the FDTD approach for the simulation of flow cytometry may open up a new avenue in the development of advanced cytometric techniques based on scattering effects from nanoscale targets.

摘要

本文在基于光散射的体内流式细胞术潜在应用框架下，介绍了时域有限差分（FDTD）方法的公式。重点考虑了在可控折射率匹配条件下单个生物细胞的光散射与金纳米颗粒标记细胞的光散射的比较。还分析了包括相衬显微镜（OPCM）作为体内流式细胞术潜在模式的光学原理图。FDTD方法用于流式细胞术模拟的验证，可能为基于纳米级目标散射效应的先进细胞术技术发展开辟一条新途径。