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透明质酸包涵体肌病:由他汀类药物治疗所揭示。

Hyaline inclusion myopathy: unmasked by statin therapy.

作者信息

Supala-Berger Agnes, Fine Edward, Heffner Reid, Young-McLain Eufrosina

出版信息

Muscle Nerve. 2009 Oct;40(4):657-61. doi: 10.1002/mus.21079.

Abstract

We report a case of a patient with history of alcohol abuse, treatment for hepatitis C and repeated strenuous physical activity who developed severe muscle pain and weakness during statin therapy. The symptoms persisted after discontinuation of the drug. The diagnosis of myopathy was made clinically and by electromyography. As his symptoms persisted a muscle biopsy was performed which showed inclusions consistent with hyaline inclusions. Hyaline inclusion myopathy is discussed in the context of this case with review of the literature.

摘要

我们报告一例有酒精滥用史、接受过丙型肝炎治疗且反复进行剧烈体力活动的患者,该患者在他汀类药物治疗期间出现严重的肌肉疼痛和无力。停药后症状仍持续存在。通过临床和肌电图检查做出了肌病的诊断。由于其症状持续存在,进行了肌肉活检,结果显示有与透明样包涵体一致的包涵体。结合该病例并复习文献对透明样包涵体肌病进行了讨论。

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