Kimber I, Cumberbatch M, Bentley A N, Baker D
ICI Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, UK.
J Clin Lab Immunol. 1990 Jun;32(2):67-72.
The requirements for the induction of antigenic competition in murine contact sensitivity have been examined. Experiments with a variety of skin-sensitizing chemicals revealed a correlation between immunogenicity and the ability to inhibit subsequent responses to an unrelated contact allergen, oxazolone. Previous studies have suggested that, in contact sensitivity at least, antigenic competition is the consequence of a reduced lymphocyte proliferative response to the second antigen. We investigated whether the regulatory events which impair proliferation following exposure to the second antigen are induced as the result of a strong proliferative response to the first (competitor) antigen. It was found, however, that significant inhibition of the primary proliferative response to picryl chloride, by pretreatment of mice with either picryl sulphonic acid or 2,4-dinitrochlorobenzene, failed to prevent picryl chloride inducing antigenic competition for oxazolone. Our studies suggest that following topical exposure to potent skin allergens events other than proliferation in draining lymph nodes induce active immunoregulatory processes, one consequence of which is the appearance of antigenic competition.
已对诱导小鼠接触性敏感反应中抗原竞争的条件进行了研究。使用多种皮肤致敏化学物质进行的实验表明，免疫原性与抑制随后对无关接触性变应原（恶唑酮）反应的能力之间存在相关性。先前的研究表明，至少在接触性敏感反应中，抗原竞争是淋巴细胞对第二种抗原增殖反应降低的结果。我们研究了暴露于第二种抗原后损害增殖的调节事件是否是对第一种（竞争）抗原强烈增殖反应的结果。然而，发现用苦味磺酸或2,4-二硝基氯苯预处理小鼠，对氯化苦基的初次增殖反应有显著抑制作用，但并不能阻止氯化苦基诱导对恶唑酮的抗原竞争。我们的研究表明，在局部暴露于强效皮肤变应原后，引流淋巴结中除增殖外的其他事件会诱导活跃的免疫调节过程，其结果之一就是出现抗原竞争。
