Polak L
Int Arch Allergy Appl Immunol. 1985;76(3):275-81. doi: 10.1159/000233705.
The antigen-presenting capability of macrophage modified with a single hapten (dinitrofluorobenzene) is partially or totally abolished by an additional haptenation with a second related (picryl chloride) or unrelated (oxazolone) hapten. This effect, 'antigenic competition', is only partially mediated by suppressor cells. There also seems to be an inhibition of the association of the hapten with particular Ia antigens. The prerequisite for antigenic competition is that both hapten responses are controlled by the same immune response gene. Hapten responses which are controlled by different genes, e.g., dinitrofluorobenzene, picryl chloride, and oxazolone on the one hand and benzilidene acetone on the other, do not compete. The pattern of competition thus varies with the strain of guinea pig.
用单一半抗原（二硝基氟苯）修饰的巨噬细胞的抗原呈递能力，会被第二种相关（苦味酰氯）或不相关（恶唑酮）半抗原的额外半抗原化部分或完全消除。这种效应，即“抗原竞争”，仅部分由抑制细胞介导。似乎还存在半抗原与特定Ia抗原结合的抑制作用。抗原竞争的前提是两种半抗原反应都由相同的免疫反应基因控制。由不同基因控制的半抗原反应，例如一方面是二硝基氟苯、苦味酰氯和恶唑酮，另一方面是亚苄基丙酮，不会发生竞争。因此，竞争模式因豚鼠品系而异。
