Gao Xiaowei, Huang Yongwrang, Liu Jing
Department of Otorhinolaryngology, the Second Hospital of Tianjin Medical University, Tianjin, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 May;23(9):407-10.
To study the expression and biological value of AQP1 and VEGF in laryngeal squamous cell carcinoma (LSCC) and their correlation.
The expressions of AQP1 and VEGF were detected with immunohistochemical SP method in 60 cases of LSCC, 22 cases of polyps of vocal cord and 30 cases of normal tissues.
The expression of AQP1 and VEGF in the laryngeal carcinoma group was significantly higher than that in polyps of vocal cord group and normal control. The expression of AQP1 and VEGF was related to the clinical staging, the differentiation degree and the lymph node metastasis. The higher was the tumor stage, the stronger was AQP1 and VEGF expression; the lower was the tumor differentiation, the stronger was AQP1 and VEGF expression. The expression of AQP1 and VEGF in the group with lymph node metastasis was higher than that in non metastasis ones; The sexuality and age did not affect the expressions of AQP1 and VEGF. The expressions was direct correlation between AQP1 and VEGF in the laryngeal carcinoma tissues.
The high expressions of AQP1 and VEGF and the close relationship with the clinical pathological factors in the LSCC, implicated that AQP1 and VEGF played an important role in the laryngeal carcinoma cells growth,metastasis and angiogenesis of LSCC.
研究水通道蛋白1（AQP1）和血管内皮生长因子（VEGF）在喉鳞状细胞癌（LSCC）中的表达、生物学意义及其相关性。
采用免疫组织化学SP法检测60例LSCC组织、22例声带息肉组织及30例正常组织中AQP1和VEGF的表达。
喉癌组织中AQP1和VEGF的表达明显高于声带息肉组和正常对照组。AQP1和VEGF的表达与临床分期、分化程度及淋巴结转移有关。肿瘤分期越高，AQP1和VEGF表达越强；肿瘤分化程度越低，AQP1和VEGF表达越强。有淋巴结转移组AQP1和VEGF的表达高于无转移组；性别和年龄不影响AQP1和VEGF的表达。喉癌组织中AQP1与VEGF的表达呈正相关。
LSCC中AQP1和VEGF的高表达及其与临床病理因素的密切关系，提示AQP1和VEGF在LSCC的癌细胞生长、转移及血管生成中起重要作用。
