Zebrowska Agnieszka, Waszczykowska Elzbieta, Wagrowska-Danilewicz Małgorzata, Danilewicz Marian, Erkiert-Polguj Anna, Pawliczak Rafał, Sysa-Jedrzejowska Anna
Department of Dermatology and Venereology, Medical University of Lodz, Lodz.
Pol J Pathol. 2009;60(1):26-34.
Dermatitis herpetiformis (DH) and bullous pemphigoid (BP) are autoimmune diseases characterized by destruction of the basement membrane zone (BMZ) and anchoring fibres by autoantibodies and infiltration. Adhesion molecules can take part in these phenomena. Skin biopsies were taken from 13 patients with DH, 21 with BP, and from 10 healthy subjects. The localization and expression of E and L selectins and beta1, beta3, beta4 integrins were studied by immunohistochemistry. Expression of selectins was detected mainly in the skin leukocytes in all samples. Expression of beta1, beta3 integrins was detected mainly in basal keratinocytes. Expression of beta 4 integrin was irregular and detected mainly in the blister. Our results suggest that integrins and selectins may play an important role in the destruction of BMZ in DH and BP. The elucidation of the role of adhesion molecules in the pathogenesis of bullous diseases may be helpful in the development of new targeted therapies.
疱疹样皮炎（DH）和大疱性类天疱疮（BP）是自身免疫性疾病，其特征是自身抗体和浸润导致基底膜带（BMZ）和锚定纤维被破坏。黏附分子可参与这些现象。对13例DH患者、21例BP患者以及10名健康受试者进行了皮肤活检。通过免疫组织化学研究了E选择素、L选择素以及β1、β3、β4整合素的定位和表达。在所有样本中，选择素的表达主要在皮肤白细胞中检测到。β1、β3整合素的表达主要在基底角质形成细胞中检测到。β4整合素的表达不规则，主要在水疱中检测到。我们的结果表明，整合素和选择素可能在DH和BP的BMZ破坏中起重要作用。阐明黏附分子在大疱性疾病发病机制中的作用可能有助于开发新的靶向治疗方法。
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