Cynkier Anna, Zebrowska Agnieszka, Wągrowska-Danilewicz Małgorzata, Danilewicz Marian, Erkiert-Polguj Anna, Stasikowska-Kanicka Olga, Sysa-Jędrzejowska Anna, Waszczykowska Elżbieta
Department of Dermatology and Venereology, Medical University of Lodz, Lodz, Poland.
Pol J Pathol. 2012 Mar;63(1):31-9.
Bullous pemphigoid (BP) and dermatitis herpetiformis (DH) are chronic subepidermal bullous diseases, which progress together with an itch and an inflammatory reaction. These symptoms may be the cause of a phenomenon described in the literature as a neurogenic skin inflammation. Neuropeptides are one of the mediators which take part in this process. The aim of our study was to indicate the expression of selected neuropeptides - CRF (corticotropin releasing factor), CGRP (calcitonin gene-related peptide), NKB (neurokinin B), SP (substance P) and the receptor for endothelin B (ETRB) - in the skin of patients suffering from BP or DH. A significantly increased expression of CRF was found in the specimen collected from the skin lesions of patients with BP and DH as well as a significantly increased expression of receptor for endothelin B in the patients with DH by the immunohistochemical method. The results obtained give evidence of a possible participation of CRF and receptor for endothelin B in the pathogenesis of the itch in the dermatitis herpetiformis as well as CRF in bullous pemphigoid.
大疱性类天疱疮（BP）和疱疹样皮炎（DH）是慢性表皮下大疱性疾病，伴有瘙痒和炎症反应。这些症状可能是文献中所描述的神经源性皮肤炎症现象的原因。神经肽是参与这一过程的介质之一。我们研究的目的是表明所选神经肽——促肾上腺皮质激素释放因子（CRF）、降钙素基因相关肽（CGRP）、神经激肽B（NKB）、P物质（SP）以及内皮素B受体（ETRB）——在BP或DH患者皮肤中的表达情况。通过免疫组织化学方法发现，从BP和DH患者皮肤病变处采集的标本中CRF表达显著增加，且DH患者中内皮素B受体的表达也显著增加。所获得的结果证明CRF和内皮素B受体可能参与疱疹样皮炎瘙痒的发病机制，以及CRF参与大疱性类天疱疮的发病机制。
