铜催化烯丙基磺酰胺的N-烯丙基化反应

Copper-catalyzed N-allenylation of allylic sulfonamides.

作者信息

Persson Andreas K A, Johnston Eric V, Bäckvall Jan-E

机构信息

Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden.

出版信息

Org Lett. 2009 Sep 3;11(17):3814-7. doi: 10.1021/ol901294j.

DOI:10.1021/ol901294j

PMID:19670851

Abstract

Allylic allenic amides have been synthesized via a copper-catalyzed cross-coupling between allylic sulfonamides and bromoallenes in moderate to good yields. Copper(I) thiophene-2-carboxylate (CuTC) was used a source of copper with DMEDA as the ligand. The allenylated products obtained are potential substrates for palladium-catalyzed carbocyclizations.

摘要

通过铜催化的烯丙基磺酰胺与溴代联烯之间的交叉偶联反应，以中等至良好的产率合成了烯丙基联烯酰胺。使用2-噻吩甲酸亚铜（CuTC）作为铜源，N,N-二甲基乙二胺（DMEDA）作为配体。所得到的联烯基化产物是钯催化碳环化反应的潜在底物。