Muller G, Zabaleta M, Caldera L H, Bianco N, Machado I V
Centro Nacional de Referencia en Inmunología Clínica, SAS-UCV.
G E N. 1990 Oct-Dec;44(4):336-42.
Five hundred serum samples from volunteers blood donors were investigated in order to determine the presence of anti-HCV antibodies by an enzyme-linked immunoassay recently developed worldwide. Prevalence of true-positive samples was 1.2% (6/500), 2 fold higher than the reported prevalence in most of the industrialized countries. From these 6 sera, one (16.6%) showed simultaneous reactivity for HBV anticore antibody. Three sera (25%) from 12 patients with diagnosis of Non-A Non-B hepatitis were reactive for anti-HCV antibodies while in a group of 32 sera with negative HAV and HBV screening, 4 (12.5%) showed anti-HCV antibodies. Two samples out of 16 sera persistently positive for anticore demonstrated the presence of anti-HCV antibodies. The anti-HCV antibodies were undetectable in two cases of autoimmune chronic hepatitis. Our results indicate that in Venezuela, HCV represents a significant problem of public health coexisting in certain cases with HBV infection.
为了通过一种最近在全球范围内开发的酶联免疫分析法确定抗丙型肝炎病毒（HCV）抗体的存在情况，对500份来自自愿献血者的血清样本进行了调查。真阳性样本的患病率为1.2%（6/500），比大多数工业化国家报告的患病率高出2倍。在这6份血清中，有1份（16.6%）对乙肝核心抗体呈同时反应性。12例诊断为非甲非乙型肝炎的患者中有3份血清（25%）对抗HCV抗体呈反应性，而在一组甲型肝炎病毒（HAV）和乙肝病毒（HBV）筛查均为阴性的32份血清中，有4份（12.5%）显示出抗HCV抗体。16份核心抗体持续阳性的血清中有2份样本显示存在抗HCV抗体。在2例自身免疫性慢性肝炎病例中未检测到抗HCV抗体。我们的结果表明，在委内瑞拉，HCV是一个重大的公共卫生问题，在某些情况下与HBV感染并存。
