Department of Ophthalmology, University Clinic, University of Navarra, Pamplona, Spain.
Ophthalmic Res. 2009;42(4):205-12. doi: 10.1159/000232946. Epub 2009 Aug 11.
To determine the role of the retinal pigment epithelium (RPE) in the development of laser-induced choroidal neovascularization (CNV) by selective damage with sodium iodate (SI).
In group 1, diode laser photocoagulation was applied to the right eye of Long-Evans rats (n = 11). In group 2 (n = 11), SI was administered intravenously at a dose of 40 mg/kg of body weight 2 days after photocoagulation. In group 3 (n = 10), SI was injected 2 days before laser was applied. In group 4 (n = 10), SI was injected immediately after photocoagulation.
CNV ingrowth developed in 42 of 93 burns (45%) of the laser group and in 46 of 75 burns (61%) when SI was administered 2 days after laser (p = 0.036). No CNV developed in the other groups.
The angiogenic effect of the RPE is essential during the first hours after the onset of the laser-induced CNV process. When the RPE was damaged before or at the time of photocoagulation, CNV was not induced. These results suggest that RPE integrity is a decisive element in CNV formation.
通过碘酸钠（SI）选择性损伤来确定视网膜色素上皮（RPE）在激光诱导脉络膜新生血管（CNV）形成中的作用。
在第 1 组中，对 Long-Evans 大鼠右眼进行二极管激光光凝（n = 11）。在第 2 组（n = 11）中，在光凝后 2 天给予 40mg/kg 体重的静脉内 SI。在第 3 组（n = 10）中，在应用激光前 2 天注射 SI。在第 4 组（n = 10）中，SI 在光凝后立即注射。
激光组 93 个烧伤中有 42 个（45%）发生 CNV 生长，SI 在激光后 2 天给药时 75 个烧伤中有 46 个（61%）发生 CNV 生长（p = 0.036）。其他组未发生 CNV。
在激光诱导的 CNV 过程开始后的最初几小时内，RPE 的血管生成作用至关重要。当 RPE 在光凝之前或同时受损时，不会诱导 CNV。这些结果表明 RPE 的完整性是 CNV 形成的决定性因素。
