Liu Allen P, Fletcher Daniel A
Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA.
Nat Rev Mol Cell Biol. 2009 Sep;10(9):644-50. doi: 10.1038/nrm2746. Epub 2009 Aug 12.
We are much better at taking cells apart than putting them together. Reconstitution of biological processes from component molecules has been a powerful but difficult approach to studying functional organization in biology. Recently, the convergence of biochemical and cell biological advances with new experimental and computational tools is providing the opportunity to reconstitute increasingly complex processes. We predict that this bottom-up strategy will uncover basic processes that guide cellular assembly, advancing both basic and applied sciences.
我们在拆解细胞方面比将它们组装起来要擅长得多。从组成分子重构生物过程一直是研究生物学功能组织的一种强大但困难的方法。最近，生物化学和细胞生物学的进展与新的实验和计算工具的融合，为重构日益复杂的过程提供了机会。我们预测，这种自下而上的策略将揭示指导细胞组装的基本过程，推动基础科学和应用科学的发展。
