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抗疱疹病毒药物5-甲氧基甲基-2'-脱氧尿苷对体内体液免疫反应的影响。

The effect of the antiherpesvirus drug 5-methoxymethyl-2'-deoxyuridine on the humoral immune response in vivo.

作者信息

Rouse B T, Babiuk L A, Gupta V S

出版信息

Can J Microbiol. 1977 Aug;23(8):1059-61. doi: 10.1139/m77-158.

DOI:10.1139/m77-158
PMID:196730
Abstract

5-Methoxymethyl-2'-deoxyuridine (MMUdR), a drug with potent antiviral activity in vitro against Herpes simplex virus, was investigated for its immunosuppressive effects. Doses as high as 2000mg/kg given daily for 9 days were not immunosupporessive as judged by the fact that treated animals produced normal immune responses to sheep erythrocytes, Brucella bacteria, and Herpes simplex virus.

摘要

5-甲氧基甲基-2'-脱氧尿苷（MMUdR）是一种在体外对单纯疱疹病毒具有强大抗病毒活性的药物，对其免疫抑制作用进行了研究。经判断，连续9天每天给予高达2000mg/kg的剂量并无免疫抑制作用，因为接受治疗的动物对绵羊红细胞、布鲁氏菌和单纯疱疹病毒产生了正常的免疫反应。

相似文献

1
The effect of the antiherpesvirus drug 5-methoxymethyl-2'-deoxyuridine on the humoral immune response in vivo.抗疱疹病毒药物5-甲氧基甲基-2'-脱氧尿苷对体内体液免疫反应的影响。
Can J Microbiol. 1977 Aug;23(8):1059-61. doi: 10.1139/m77-158.
2
Combination chemotherapy: interaction of 5-methoxymethyldeoxyuridine with adenine arabinoside, 5-ethyldeoxyuridine, 5-iododeoxyuridine, and phosphonoacetic acid against herpes simplex virus types 1 and 2.联合化疗：5-甲氧基甲基脱氧尿苷与阿糖腺苷、5-乙基脱氧尿苷、5-碘脱氧尿苷及膦甲酸对1型和2型单纯疱疹病毒的相互作用
Antimicrob Agents Chemother. 1980 Apr;17(4):558-66. doi: 10.1128/AAC.17.4.558.
3
Pharmacological studies on 5-methoxymethyl-2'-deoxyuridine: a new antiviral agent.5-甲氧基甲基-2'-脱氧尿苷的药理学研究：一种新型抗病毒剂。
J Pharmacol Exp Ther. 1981 Feb;216(2):275-80.
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Factors determining the effects of chronic protein-deficiency on antibody responses to sheep red blood cells and Brucella abortus vaccine in mice.决定慢性蛋白质缺乏对小鼠抗绵羊红细胞及流产布鲁氏菌疫苗抗体反应影响的因素。
Aust J Exp Biol Med Sci. 1977 Feb;55(1):59-78. doi: 10.1038/icb.1977.6.
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Comparison of the antiviral effects of 5-methoxymethyl-deoxyuridine with 5-iododeoxyuridine, cytosine arabinoside, and adenine arabinoside.5-甲氧基甲基脱氧尿苷与5-碘脱氧尿苷、阿糖胞苷和阿糖腺苷抗病毒效果的比较。
Antimicrob Agents Chemother. 1975 Dec;8(6):643-50. doi: 10.1128/AAC.8.6.643.
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Immune responses and prevention of lymphoid leukosis tumors in chickens fed an androgen analog.喂食雄激素类似物的鸡的免疫反应及淋巴白血病肿瘤的预防
Adv Exp Med Biol. 1977;88:355-62. doi: 10.1007/978-1-4613-4169-7_33.
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Modification of humoral immune response in chickens following treatment with carrageenan.角叉菜胶处理后鸡的体液免疫反应的改变。
Vet Immunol Immunopathol. 1984 Oct;7(3-4):347-57. doi: 10.1016/0165-2427(84)90092-8.
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Relationship between structure and antiviral activity of 5-methoxymethyl-2'-deoxyuridine and 5-methoxymethyl-1-(2'-deoxy-beta-D-lyxofuranosyl)uracil.5-甲氧基甲基-2'-脱氧尿苷与5-甲氧基甲基-1-(2'-脱氧-β-D-呋喃来苏糖基)尿嘧啶的结构与抗病毒活性之间的关系
Antiviral Res. 1987 Feb;7(2):69-77. doi: 10.1016/0166-3542(87)90022-2.
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Arabinosylthymine: suppressor of hamster immunoglobulin M formation during primary immune response.阿拉伯糖基胸腺嘧啶：初次免疫应答期间仓鼠免疫球蛋白M形成的抑制剂。
Infect Immun. 1980 Apr;28(1):160-2. doi: 10.1128/iai.28.1.160-162.1980.
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Immunobiological studies with the virostatics 5-ethyl-2'-deoxyuridine (EDU) and 1-allyl-3,5-diethyl-6-chlorouracil (ACIU).使用病毒抑制剂5-乙基-2'-脱氧尿苷（EDU）和1-烯丙基-3,5-二乙基-6-氯尿嘧啶（ACIU）的免疫生物学研究。
Chemotherapy. 1969;14(3):129-32. doi: 10.1159/000220621.

引用本文的文献

1
Combination chemotherapy: interaction of 5-methoxymethyldeoxyuridine with adenine arabinoside, 5-ethyldeoxyuridine, 5-iododeoxyuridine, and phosphonoacetic acid against herpes simplex virus types 1 and 2.联合化疗：5-甲氧基甲基脱氧尿苷与阿糖腺苷、5-乙基脱氧尿苷、5-碘脱氧尿苷及膦甲酸对1型和2型单纯疱疹病毒的相互作用
Antimicrob Agents Chemother. 1980 Apr;17(4):558-66. doi: 10.1128/AAC.17.4.558.