抗疱疹病毒药物5-甲氧基甲基-2'-脱氧尿苷对体内体液免疫反应的影响。
The effect of the antiherpesvirus drug 5-methoxymethyl-2'-deoxyuridine on the humoral immune response in vivo.
作者信息
Rouse B T, Babiuk L A, Gupta V S
出版信息
Can J Microbiol. 1977 Aug;23(8):1059-61. doi: 10.1139/m77-158.
DOI:10.1139/m77-158
PMID:196730
Abstract
5-Methoxymethyl-2'-deoxyuridine (MMUdR), a drug with potent antiviral activity in vitro against Herpes simplex virus, was investigated for its immunosuppressive effects. Doses as high as 2000mg/kg given daily for 9 days were not immunosupporessive as judged by the fact that treated animals produced normal immune responses to sheep erythrocytes, Brucella bacteria, and Herpes simplex virus.
摘要
5-甲氧基甲基-2'-脱氧尿苷（MMUdR）是一种在体外对单纯疱疹病毒具有强大抗病毒活性的药物，对其免疫抑制作用进行了研究。经判断，连续9天每天给予高达2000mg/kg的剂量并无免疫抑制作用，因为接受治疗的动物对绵羊红细胞、布鲁氏菌和单纯疱疹病毒产生了正常的免疫反应。
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