阿拉伯糖基胸腺嘧啶：初次免疫应答期间仓鼠免疫球蛋白M形成的抑制剂。
Arabinosylthymine: suppressor of hamster immunoglobulin M formation during primary immune response.
作者信息
Barnett J M, McGowan J J, Gentry G A
出版信息
Infect Immun. 1980 Apr;28(1):160-2. doi: 10.1128/iai.28.1.160-162.1980.
The effect of 1-beta-D-arabinofuranosylthymine (araT) and thymidine (TdR) on the primary and secondary humoral immune responses to Brucella abortus and sheep erythrocytes was investigated. The data indicate that both agents suppress the primary humoral response without significantly altering the secondary response. In addition, the mercaptoethanol-sensitive immunoglobulin component of the total antibody titer was lowered to a much greater extent than was the mercaptoethanol-resistant immunoglobulin component by treatment with ara-T or TdR. Further, the response to B. abortus (a T-independent antigen) seemed to be suppressed more than the response to sheep erythrocytes, a T-dependent antigen. This suggests that subpopulations of lymphocytes may express different sensitivities to araT and TdR.
研究了1-β-D-阿拉伯呋喃糖基胸腺嘧啶核苷（araT）和胸腺嘧啶核苷（TdR）对布鲁氏菌流产株和绵羊红细胞的初次和二次体液免疫反应的影响。数据表明，这两种药物均抑制初次体液反应，而对二次反应无明显改变。此外，与巯基乙醇抗性免疫球蛋白成分相比，用ara-T或TdR处理后，总抗体效价中对巯基乙醇敏感的免疫球蛋白成分降低的程度要大得多。此外，对布鲁氏菌流产株（一种非T细胞依赖性抗原）的反应似乎比对绵羊红细胞（一种T细胞依赖性抗原）的反应抑制作用更强。这表明淋巴细胞亚群对araT和TdR可能表现出不同的敏感性。
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