Martinez-Hernandez A, Francis D J, Silverberg S G
Cancer. 1977 Aug;40(2):600-6. doi: 10.1002/1097-0142(197708)40:2<700::aid-cncr2820400217>3.0.co;2-w.
The stroma and stromal reaction in normal breast, benign, and malignant breast tissue was studied by electron microscopy. Elastosis is the main stromal response in infiltrating duct and lobular carcinomas. Medullary carcinoma elicits no significant elastosis but intraductal carcinoma has significant local elastosis. Benign conditions such as fibroadenoma and sclerosing adenosis produced no significant elastosis. The high number of elastic fibers and the high microfibril:elastin ratio indicate that most of the elastic fibers are recently secreted, probably by fibroblasts and myofibroblasts. The factors stimulating the increased production of elastic fibers and the prognostic significance of elastosis remain unclear.
通过电子显微镜研究了正常乳腺、良性乳腺组织和恶性乳腺组织中的基质及基质反应。弹性组织变性是浸润性导管癌和小叶癌的主要基质反应。髓样癌未引发明显的弹性组织变性，但导管内癌有明显的局部弹性组织变性。诸如纤维腺瘤和硬化性腺病等良性病变未产生明显的弹性组织变性。大量的弹性纤维以及高微原纤维与弹性蛋白比例表明，大多数弹性纤维是最近分泌的，可能由成纤维细胞和平滑肌成纤维细胞分泌。刺激弹性纤维产生增加的因素以及弹性组织变性的预后意义仍不清楚。
