Mera S L, Davies J D
J Pathol. 1987 Feb;151(2):103-10. doi: 10.1002/path.1711510202.
Elastosis associated with invasive ductal and lobular carcinomas of the breast was examined by tinctorial and immunohistochemical staining methods, enzyme digestion, and electron microscopy. The elastotic material exhibited the tinctorial staining properties of elastic fibres, and the ultrastructural appearances were those of elastic fibres although there was a higher proportion of microfibrils than in normal mature elastic fibres. The elastosis was immunostained by antisera to human fetal elastin, lysozyme and amyloid P component, as in other sites where elastic fibres are found. These findings indicate that immunohistochemically intact elastic fibres are present in the elastosis of breast cancer. They also demonstrate that lysozyme and amyloid P component are co-distributed with elastic fibres in elastosis of breast carcinoma, as distinct components with different susceptibilities to enzyme digestion. The cellular origin of elastosis in breast carcinoma remains uncertain.
采用染色、免疫组织化学染色方法、酶消化及电子显微镜检查，对乳腺浸润性导管癌和小叶癌相关的弹性组织变性进行了研究。弹性组织变性物质呈现出弹性纤维的染色特性，尽管微原纤维的比例高于正常成熟弹性纤维，但其超微结构表现仍为弹性纤维。与在发现弹性纤维的其他部位一样，弹性组织变性对人胎儿弹性蛋白、溶菌酶及淀粉样P成分的抗血清呈免疫染色阳性。这些发现表明，乳腺癌弹性组织变性中存在免疫组织化学完整的弹性纤维。它们还证明，在乳腺癌弹性组织变性中，溶菌酶和淀粉样P成分与弹性纤维共同分布，是对酶消化敏感性不同的不同成分。乳腺癌弹性组织变性的细胞起源仍不确定。
