Parfrey N A, Doyle C T
Hum Pathol. 1985 Jul;16(7):674-6. doi: 10.1016/s0046-8177(85)80150-7.
Elastosis, the presence of clumps of elastic fibers, is known to occur frequently in association with breast carcinoma. To test the hypothesis that the degree of elastosis increases progressively in fibrocystic disease with the severity of epitheliosis (epithelial hyperplasia, papillomatosis; widely believed to be the only premalignant component of fibrocystic disease) and increases further with intraductal and infiltrating duct carcinoma, breast tissue stained for elastic fibers from 84 women in the fifth decade of life was studied. Fourteen cases were evaluated in each of six disease categories: fibrocystic disease without epitheliosis; fibrocystic disease with epitheliosis, graded subjectively as mild, moderate, or severe (based on the degree of epithelial hyperplasia); intraductal carcinoma; and infiltrating duct carcinoma of the breast. Periductal elastosis and stromal elastosis were graded on a scale of 0 to 4 (absent to massive). The grades of both periductal elastosis and stromal elastosis were compared with those for the six disease categories ranked by increasingly advanced disease. The results indicate that the grades of periductal elastosis (Spearman rank correlation coefficient [R] = 0.54; P less than 0.001) and stromal elastosis (R = 0.75; P less than 0.001) increase progressively with the severity of breast disease.
弹性组织变性，即弹性纤维团块的存在，已知常与乳腺癌相关。为了验证这一假说，即弹性组织变性的程度在纤维囊性疾病中随着上皮增生（上皮细胞增生、乳头状瘤病；普遍认为是纤维囊性疾病唯一的癌前病变成分）的严重程度而逐渐增加，并在导管内癌和浸润性导管癌中进一步增加，研究了84名50岁左右女性的乳腺组织弹性纤维染色情况。对六个疾病类别中的每一类14个病例进行了评估：无上皮增生的纤维囊性疾病；有上皮增生的纤维囊性疾病，主观分级为轻度、中度或重度（基于上皮细胞增生程度）；导管内癌；以及乳腺浸润性导管癌。导管周围弹性组织变性和间质弹性组织变性按0至4级（无至大量）分级。将导管周围弹性组织变性和间质弹性组织变性的分级与按疾病进展程度递增排列的六个疾病类别的分级进行比较。结果表明，导管周围弹性组织变性分级（斯皮尔曼等级相关系数[R]=0.54；P<0.001）和间质弹性组织变性分级（R=0.75；P<0.001）随着乳腺疾病的严重程度而逐渐增加。
