Barr R J, Wuerker R B, Graham J H
Cancer. 1977 Aug;40(2):736-43. doi: 10.1002/1097-0142(197708)40:2<736::aid-cncr2820400222>3.0.co;2-p.
Electron microscopic examination of an atypical fibroxanthoma (AFX) confirmed the fibrohistiocytic nature of this lesion. Ultrastructural evidence suggested a transition from fibroblasts to large giant cells with intermediate forms exhibiting features of both. A comparison of AFX ultrastructural features to those of other similar neoplasms suggested a possible relationship to malignant fibrous histiocytoma. As diagnosed by light microscopy, AFX probably represents a spectrum of neoplasms; this concept is discussed. It is urged, when possible, that electron microscopy be performed on lesions diagnosed as atypical fibroxanthoma since ultrastructure studies represent the most valid basis on which a correct diagnosis can be made.
对非典型纤维黄色瘤（AFX）进行电子显微镜检查证实了该病变的纤维组织细胞性质。超微结构证据表明从成纤维细胞向大的巨细胞转变，中间形式同时具有两者的特征。将AFX的超微结构特征与其他类似肿瘤的特征进行比较，提示其与恶性纤维组织细胞瘤可能存在关联。如通过光学显微镜诊断，AFX可能代表一系列肿瘤；对此概念进行了讨论。敦促在可能的情况下，对诊断为非典型纤维黄色瘤的病变进行电子显微镜检查，因为超微结构研究是做出正确诊断的最有效依据。
