Sun C C, Toker C, Breitenecker R
Cancer. 1982 May 15;49(10):2103-11. doi: 10.1002/1097-0142(19820515)49:10<2103::aid-cncr2820491023>3.0.co;2-3.
We studied the electron microscopy of two tumors which clinically and histologically conformed to what has been described as angiomatoid fibrous histiocytoma, a tumor thought to be of fibrohistiocytic origin. The ultrastructure of one tumor was that of a cellular angioma and the second tumor a vascular lesion with fibroblasts and histiocyte-like mononuclear cells. Our findings suggest that angiomatoid fibrous histiocytomas are basically vascular tumors with fibroblasts and other cells as secondary participants in some lesions. The behaviour of angiomatoid fibrous histiocytoma cannot be predicted from histology. Our findings of different ultrastructural components in histologically non-separable tumors lead to a question whether different ultrastructural composition is correlated with different biological behavior of these tumors. Further studies of similar cases are required if tumor morphology is to be correlated with clinical behavior.
我们研究了两例肿瘤的电子显微镜检查结果，这两例肿瘤在临床和组织学上均符合所谓的血管样纤维组织细胞瘤，一种被认为起源于纤维组织细胞的肿瘤。其中一例肿瘤的超微结构表现为细胞性血管瘤，另一例为伴有成纤维细胞和组织细胞样单核细胞的血管性病变。我们的研究结果表明，血管样纤维组织细胞瘤基本上是血管性肿瘤，在某些病变中，成纤维细胞和其他细胞是次要参与者。血管样纤维组织细胞瘤的行为无法从组织学上预测。我们在组织学上无法区分的肿瘤中发现了不同的超微结构成分，这引发了一个问题，即不同的超微结构组成是否与这些肿瘤的不同生物学行为相关。如果要将肿瘤形态与临床行为相关联，则需要对类似病例进行进一步研究。
