Quan Taihao, Qin Zhaoping, Xia Wei, Shao Yuan, Voorhees John J, Fisher Gary J
Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
J Investig Dermatol Symp Proc. 2009 Aug;14(1):20-4. doi: 10.1038/jidsymp.2009.8.
UV radiation from the sun impacts skin health adversely through complex, multiple molecular pathways. Premature skin aging (photoaging) is among the most widely appreciated harmful effects of chronic exposure to solar UV radiation. Extensive damage to the dermal connective tissue is a hallmark of photoaged skin. Disruption of the normal architecture of skin connective tissue impairs skin function and causes it to look aged. UV irradiation induces expression of certain members of the matrix metalloproteinase (MMP) family, which degrade collagen and other extracellular matrix proteins that comprise the dermal connective tissue. Although the critical role of MMPs in photoaging is undeniable, important questions remain. This article summarizes our current understanding of the role of MMPs in the photoaging process and presents new data that (1) describe the expression and regulation by UV irradiation of all members of the MMP family in human skin in vivo and (2) quantify the relative contributions of epidermis and dermis to the expression of UV irradiation-induced MMPs in human skin in vivo.Journal of Investigative Dermatology Symposium Proceedings (2009) 14, 20-24; doi:10.1038/jidsymp.2009.8.
来自太阳的紫外线通过复杂的多种分子途径对皮肤健康产生不利影响。皮肤过早老化（光老化）是长期暴露于太阳紫外线辐射最广为人知的有害影响之一。真皮结缔组织的广泛损伤是光老化皮肤的一个标志。皮肤结缔组织正常结构的破坏会损害皮肤功能并使其看起来老化。紫外线照射会诱导基质金属蛋白酶（MMP）家族某些成员的表达，这些成员会降解构成真皮结缔组织的胶原蛋白和其他细胞外基质蛋白。尽管MMPs在光老化中的关键作用不可否认，但重要问题仍然存在。本文总结了我们目前对MMPs在光老化过程中作用的理解，并呈现了新的数据，这些数据（1）描述了紫外线照射在体内对人皮肤中MMP家族所有成员的表达和调控，（2）量化了表皮和真皮对紫外线照射诱导的MMPs在体内人皮肤中表达的相对贡献。《皮肤病学研究杂志研讨会论文集》（2009年）14卷，20 - 24页；doi:10.1038/jidsymp.2009.8
