Navarro Pau, Castillo Julián, Jones Jonathan, García Adrián, Caturla Nuria
Research and Development Department, Monteloeder SL, Miguel Servet 16, 03203 Elche, Spain.
Food Technology & Nutritional Department, Universidad Católica San Antonio de Murcia (UCAM), Campus de los Jerónimos, Carretera Guadalupe, 30107 Murcia, Spain.
Int J Mol Sci. 2025 Apr 23;26(9):4001. doi: 10.3390/ijms26094001.
Skin exposure to ultraviolet radiation (UVR) causes oxidative stress, inflammation, and collagen degradation and can trigger erythema. While topical formulas protect the skin from UV damage, there is growing evidence that certain botanical ingredients taken orally may have an added benefit. This study evaluated the photoprotective, anti-photoaging, and anti-erythema efficacy of a combination of rosemary and grapefruit extract (Nutroxsun). Radical oxygen species (ROS) generation and interleukin production were determined in UV-irradiated keratinocytes (HaCaT). Also, collagen and elastin secretion and metalloproteinase (MMP-1 and MMP-3) content were assessed in UV-irradiated fibroblasts (NHDFs). Furthermore, a placebo-controlled, randomized, crossover study was conducted in 20 subjects (phototypes I to III) receiving two doses, 100 and 200 mg, of the ingredient. Skin redness (a* value, CIELab) after exposure to one minimal erythemal dose of UVR was assessed. As a result, the botanical blend significantly attenuated the UVR-induced reductions of procollagen I and elastin and lowered MMP-1 and MMP-3 protein secretion. Also, a reduction in ROS and proinflammatory interleukins (IL-1, IL-8, and IL-6) was observed. Finally, the botanical blend, at both doses, significantly reduced UV-induced erythema reaction from the first day of intake and accelerated recovery. These findings reinforce the potential of this ingredient as an effective dietary solution to protect the skin against UV-induced damage.
皮肤暴露于紫外线辐射（UVR）会导致氧化应激、炎症和胶原蛋白降解，并可能引发红斑。虽然局部配方可保护皮肤免受紫外线伤害，但越来越多的证据表明，某些口服植物成分可能具有额外益处。本研究评估了迷迭香和葡萄柚提取物组合（Nutroxsun）的光保护、抗光老化和抗红斑功效。在紫外线照射的角质形成细胞（HaCaT）中测定活性氧（ROS）生成和白细胞介素产生。此外，在紫外线照射的成纤维细胞（NHDFs）中评估胶原蛋白和弹性蛋白分泌以及金属蛋白酶（MMP - 1和MMP - 3）含量。此外，对20名受试者（光型I至III）进行了一项安慰剂对照、随机、交叉研究，受试者接受100毫克和200毫克两种剂量的该成分。评估了暴露于一个最小红斑剂量的紫外线辐射后皮肤发红情况（a*值，CIELab）。结果，植物混合物显著减轻了紫外线诱导的I型前胶原蛋白和弹性蛋白的减少，并降低了MMP - 1和MMP - 3蛋白分泌。此外，观察到ROS和促炎白细胞介素（IL - 1、IL - 8和IL - 6）减少。最后，两种剂量的植物混合物从摄入第一天起就显著减少了紫外线诱导的红斑反应，并加速了恢复。这些发现强化了该成分作为一种有效饮食解决方案来保护皮肤免受紫外线诱导损伤的潜力。
