Schwarz Thomas, Schwarz Agatha
Department of Dermatology, University Kiel, Kiel, Germany.
J Investig Dermatol Symp Proc. 2009 Aug;14(1):63-6. doi: 10.1038/jidsymp.2009.3.
As sunscreens do not provide complete protection against solar/UV radiation, alternative protective strategies are necessary to cope with the increasing incidence of skin cancer. These strategies include the reduction of UVR-induced DNA damage by the topical application of bacterial DNA repair enzymes. Recent evidence suggests that nucleotide excision repair, the physiological repair system that is mostly responsible for the removal of UVR-mediated DNA damage, can be modulated by cytokines, including IL-12, IL-18, and alpha-melanocyte-stimulating hormone. The mechanisms involved and the biological as well as the potential therapeutic implications of these findings are discussed.Journal of Investigative Dermatology Symposium Proceedings (2009) 14, 63-66; doi:10.1038/jidsymp.2009.3.
由于防晒霜不能提供针对太阳/紫外线辐射的完全防护，因此需要采取其他防护策略来应对皮肤癌发病率的不断上升。这些策略包括通过局部应用细菌DNA修复酶来减少紫外线辐射诱导的DNA损伤。最近的证据表明，核苷酸切除修复是主要负责去除紫外线介导的DNA损伤的生理修复系统，它可被包括白细胞介素-12、白细胞介素-18和α-黑素细胞刺激素在内的细胞因子调节。本文讨论了其中涉及的机制以及这些发现的生物学意义和潜在治疗意义。《皮肤病学研究杂志研讨会论文集》（2009年）14卷，63 - 66页；doi:10.1038/jidsymp.2009.3
