Ho L T, Chang Z Y, Wang J T, Li S H, Liu Y F, Chen Y D, Reaven G M
Department of Medicine, Veterans General Hospital, Taipei, Taiwan, Republic of China.
Diabet Med. 1990 Jan;7(1):31-4. doi: 10.1111/j.1464-5491.1990.tb01303.x.
Measurements were made of the plasma glucose and insulin responses to a 75 g oral glucose challenge in 50 Chinese born in Taiwan, divided into two groups on the basis of family history of Type 2 diabetes. Twenty-five individuals (age 29 +/- 5 (+/- SD) years) had 2 parents with normal oral glucose tolerance, whereas at least 1 parent had Type 2 diabetes in the other 25 subjects (age 30 +/- 6 years). In addition, in vivo insulin action was estimated by determining the steady-state plasma glucose concentration during a 3-h continuous infusion of glucose, insulin, and somatostatin. Steady-state plasma glucose concentration was used as a measure of insulin-induced glucose disposal. The 50 subjects were non-obese, and of comparable gender distribution and body mass index. Plasma glucose and insulin concentrations in response to oral glucose were similar in the two groups. However, the steady-state plasma glucose concentration was significantly (p less than 0.01) higher in offspring with a family history of Type 2 diabetes when compared by two-way analysis of variance (mean +/- SE was 5.87 +/- 0.27 vs 5.12 +/- 0.32 mmol l-1). This difference was found despite a significantly (p less than 0.01) higher steady-state plasma insulin concentration during the infusion studies (0.705 +/- 0.027 vs 0.643 +/- 0.025 nmol l-1) in offspring of people with diabetes. The results support the view that resistance to insulin-stimulated glucose uptake is present in offspring of diabetic parents.
对50名出生于台湾的中国人进行了测量，以检测他们在口服75克葡萄糖后的血浆葡萄糖和胰岛素反应。这些人根据2型糖尿病家族史分为两组。25名个体（年龄29±5（±标准差）岁）的父母口服葡萄糖耐量正常，而另外25名受试者（年龄30±6岁）中至少有1名父母患有2型糖尿病。此外，通过在3小时持续输注葡萄糖、胰岛素和生长抑素期间测定稳态血浆葡萄糖浓度来评估体内胰岛素作用。稳态血浆葡萄糖浓度用作胰岛素诱导的葡萄糖处置的指标。这50名受试者均不肥胖，性别分布和体重指数相当。两组口服葡萄糖后的血浆葡萄糖和胰岛素浓度相似。然而，通过双向方差分析比较，有2型糖尿病家族史的后代的稳态血浆葡萄糖浓度显著更高（p<0.01）（平均值±标准误为5.87±0.27 vs 5.12±0.32 mmol l-1）。尽管在输注研究期间糖尿病患者后代的稳态血浆胰岛素浓度显著更高（p<0.01）（0.705±0.027 vs 0.643±0.025 nmol l-1），但仍发现了这种差异。结果支持这样一种观点，即糖尿病父母的后代存在对胰岛素刺激的葡萄糖摄取的抵抗。
