Ensinck J W, Vogel R E, Laschansky E C, Francis B H
Department of Medicine, University of Washington, Seattle.
Gastroenterology. 1990 Mar;98(3):633-8. doi: 10.1016/0016-5085(90)90282-6.
The level of somatostatin-28, a bioactive peptide derived from pro-somatostatin in gastrointestinal epithelial cells, increases in human plasma after food intake. To determine if an equivalent response occurs with individual components of a mixed meal, somatostatin-28 and prosomatostatin, somatostatin-14, and somatostatin-13, in combination, were measured in healthy men before and after intake of (a) a mixed meal (715 kcal), (b) carbohydrate (100 g equivalent glucose), (c) protein (22 and 45 g), and (d) fat (25 and 50 g). After the mixed meal, somatostatin-28 levels doubled within 120 min and gradually declined by 4 h. With carbohydrate, somatostatin-28 levels were unaltered. After 22 and 45 g of protein, somatostatin-28 increased equivalently within 60 min, representing 30% of the amount with the mixed meal. With 25 g fat, a somatostatin-28 increase similar to that with the meal was seen; this response was doubled with 50 g fat. No changes in prosomatostatin, somatostatin-14, or somatostatin-13 were observed with the mixed meal or with the separate macronutrients. The authors conclude that fat is the major stimulus for somatostatin-28 secretion in humans and hypothesize that somatostatin-28 is an inhibitor of the endocrine and exocrine pancreas during nutrient absorption.
生长抑素-28是一种由胃肠道上皮细胞中的前生长抑素衍生而来的生物活性肽，进食后人体血浆中其水平会升高。为了确定混合餐的各个成分是否会产生类似反应，研究人员对健康男性在摄入以下食物前后的生长抑素-28、前生长抑素、生长抑素-14和生长抑素-13进行了联合测定：(a) 一顿混合餐（715千卡）；(b) 碳水化合物（100克等量葡萄糖）；(c) 蛋白质（22克和45克）；(d) 脂肪（25克和50克）。进食混合餐后，生长抑素-28水平在120分钟内翻倍，并在4小时内逐渐下降。摄入碳水化合物后，生长抑素-28水平未发生变化。摄入22克和45克蛋白质后，生长抑素-28在60分钟内等量增加，相当于混合餐时增加量的30%。摄入25克脂肪后，生长抑素-28的增加情况与进食混合餐时相似；摄入50克脂肪时，这种反应翻倍。进食混合餐或单独的常量营养素后，未观察到前生长抑素、生长抑素-14或生长抑素-13有变化。作者得出结论，脂肪是人类生长抑素-28分泌的主要刺激因素，并推测生长抑素-28在营养吸收过程中是内分泌和外分泌胰腺的抑制剂。
