Jansen R W, Peeters T L, Van Lier H J, Hoefnagels W H
Department of Geriatric Medicine, University Hospital Nijmegen, The Netherlands.
Eur J Clin Invest. 1990 Apr;20(2):192-8. doi: 10.1111/j.1365-2362.1990.tb02268.x.
In elderly subjects blood pressure (BP) may fall after a meal. It can be reproduced by oral glucose, but the effect of fat and protein ingestion on postprandial BP has not been reported. Furthermore, we hypothesized that vasoactive gastrointestinal peptides are involved in this phenomenon. We studied 10 hypertensive elderly subjects (mean age 74 +/- 3 years) for the effects of oral glucose, fat, protein and water loading on BP in relation to plasma concentrations of vasoactive intestinal polypeptide (VIP), somatostatin and insulin. Glucose loading resulted in a decrease of mean arterial pressure by 14 +/- 2 mmHg (P less than or equal to 0.001). In contrast, the ingestion of fat, protein or water had no significant effect on BP. Somatostatin increased after fat and protein loading, whereas VIP increased only after fat loading. These data indicate that postprandial BP reduction in the elderly is related to glucose-related factors. The gut peptide VIP does not seem to play a role in this phenomenon.
在老年受试者中，餐后血压（BP）可能会下降。口服葡萄糖可重现这种情况，但脂肪和蛋白质摄入对餐后血压的影响尚未见报道。此外，我们推测血管活性胃肠肽参与了这一现象。我们研究了10名高血压老年受试者（平均年龄74±3岁），观察口服葡萄糖、脂肪、蛋白质和水负荷对血压的影响，并与血管活性肠肽（VIP）、生长抑素和胰岛素的血浆浓度进行关联分析。葡萄糖负荷导致平均动脉压下降14±2 mmHg（P≤0.001）。相比之下，摄入脂肪、蛋白质或水对血压没有显著影响。脂肪和蛋白质负荷后生长抑素增加，而仅脂肪负荷后VIP增加。这些数据表明，老年人餐后血压降低与葡萄糖相关因素有关。肠道肽VIP似乎在这一现象中不起作用。
