Olsen O, Holst J J, Schaffalitzky De Muckadell O B
Surgical Department C, Rigshospitalet, University of Copenhagen, Denmark.
Dig Dis Sci. 1992 Jul;37(7):1025-8. doi: 10.1007/BF01300282.
We studied the effects of intraduodenal oleic acid on the release of somatostatin to plasma and the correlation between endogenous bile output and plasma somatostatin. In five normal persons infusion of 0, 5, 10, 20, and 40 mM oleic acid dose-dependently increased the levels of somatostatin during as well as after gallbladder emptying. The difference between somatostatin concentration during and after gallbladder emptying was not significant. The amylase secretion also was significantly correlated to the dose of fat, whereas the output of bile salts was the same for all fat doses used. Our observations indicate that intraduodenal oleic acid--and not bile salts--releases somatostatin from the gut.
我们研究了十二指肠内注入油酸对生长抑素释放至血浆的影响以及内源性胆汁分泌量与血浆生长抑素之间的相关性。在5名正常人中，分别输注0、5、10、20和40 mM的油酸，结果显示在胆囊排空期间及之后，生长抑素水平呈剂量依赖性升高。胆囊排空期间和之后生长抑素浓度的差异不显著。淀粉酶分泌也与脂肪剂量显著相关，而所有使用的脂肪剂量下胆盐分泌量相同。我们的观察结果表明，是十二指肠内的油酸而非胆盐从肠道释放出生长抑素。
