van den Brom W E, Rothuizen J
Department of Clinical Sciences of Companion Animals, University of Utrecht, The Netherlands.
Am J Vet Res. 1990 Feb;51(2):249-52.
The hepatobiliary dynamics of a 99mTc-labeled derivative of iminodiacetate were investigated in 29 healthy dogs. A 2-compartment model proved to be adequate to describe the hepatic time-activity curve. Model-derived variables for the hepatic accumulation and the biliary excretion and transport were used as a reference for evaluation of a number of commonly used measurements directly derived from hepatic and biliary time-activity curves (graphic variables). The difference between t50(ex) and t95(ex), representing the moments when 50 and 95%, respectively, of the maximal count rate during the hepatic excretory phase were measured, proved to be an adequate graphic variable to quantitate biliary excretion. The use of other graphic variables to quantitate hepatobiliary functions seemed unjustified.
在29只健康犬中研究了亚氨基二乙酸的99mTc标记衍生物的肝胆动力学。结果表明，二室模型足以描述肝脏时间-活性曲线。将模型推导的肝脏摄取、胆汁排泄和转运变量用作评估一些直接从肝脏和胆汁时间-活性曲线得出的常用测量值（图形变量）的参考。t50(ex)和t95(ex)分别代表肝脏排泄期最大计数率的50%和95%时的时间点，两者之差被证明是定量胆汁排泄的合适图形变量。使用其他图形变量来定量肝胆功能似乎没有依据。
