Spruss Astrid, Bergheim Ina
Department of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany.
J Nutr Biochem. 2009 Sep;20(9):657-62. doi: 10.1016/j.jnutbio.2009.05.006.
Worldwide, not only the prevalence of obesity has increased dramatically throughout the last three decades but also the incidences of co-morbid conditions such as diabetes type 2 and liver disease have increased. The 'hepatic manifestation of the metabolic syndrome' is called nonalcoholic fatty liver disease (NAFLD) and comprises a wide spectrum of stages of liver disease ranging from simple steatosis to liver cirrhosis. NAFLD of different stages is found in approximately 30% of adults and approximately 20% in the US population. Not just a general overnutrition but also an elevated intake of certain macronutrients such as fat and carbohydrates and herein particularly fructose has been claimed to be risk factors for the development for NAFLD; however, the etiology of this disease is still unknown. The present review outlines some of the potential mechanisms associated with the development of NAFLD and fructose intake with a particular focus on the role of the intestinal barrier functions.
在全球范围内，不仅肥胖症的患病率在过去三十年中急剧上升，而且诸如2型糖尿病和肝病等合并症的发病率也有所增加。代谢综合征的“肝脏表现”被称为非酒精性脂肪性肝病（NAFLD），它包括从单纯性脂肪变性到肝硬化等广泛的肝病阶段。不同阶段的NAFLD在约30%的成年人中被发现，在美国人群中约为20%。不仅一般的营养过剩，而且某些宏量营养素如脂肪和碳水化合物，尤其是果糖的摄入量增加，被认为是NAFLD发生发展的危险因素；然而，这种疾病的病因仍然未知。本综述概述了一些与NAFLD发生发展以及果糖摄入相关的潜在机制，特别关注肠道屏障功能的作用。
