Nebes V L, DeFranco D, Morris S M
Department of Microbiology, Biochemistry and Molecular Biology, University of Pittsburgh, PA 15261.
Biochem Biophys Res Commun. 1990 Jan 15;166(1):133-8. doi: 10.1016/0006-291x(90)91921-e.
Dexamethasone rapidly stimulated transcription of the tyrosine aminotransferase and metallothionein-I genes--but not of the phosphoenolpyruvate carboxykinase gene--in rat hepatocytes cultured in serum-free medium. This differential response was not observed for cyclic AMP. The results suggest that the phosphoenolpyruvate carboxykinase gene--but not the tyrosine aminotransferase and metallothionein-I genes--requires a factor which is permissive for stimulation of transcription by the glucocorticoid receptor.
在无血清培养基中培养的大鼠肝细胞中，地塞米松能迅速刺激酪氨酸转氨酶和金属硫蛋白-I基因的转录，但不能刺激磷酸烯醇式丙酮酸羧激酶基因的转录。环磷酸腺苷未观察到这种差异反应。结果表明，磷酸烯醇式丙酮酸羧激酶基因（而非酪氨酸转氨酶和金属硫蛋白-I基因）需要一种因子，该因子允许糖皮质激素受体刺激转录。
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