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1
Induction of mRNA for phosphoenolpyruvate carboxykinase (GTP) by dexamethasone in cultured rat hepatocytes requires on-going protein synthesis.地塞米松在培养的大鼠肝细胞中诱导磷酸烯醇丙酮酸羧激酶（GTP）的mRNA生成需要持续的蛋白质合成。
Biochem J. 1987 Aug 15;246(1):237-40. doi: 10.1042/bj2460237.
2
Mechanism of the permissive action of dexamethasone on the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene in cultured rat hepatocytes.地塞米松对培养的大鼠肝细胞中磷酸烯醇式丙酮酸羧激酶基因的胰高血糖素依赖性激活的允许作用机制。
Eur J Biochem. 1991 Jun 15;198(3):641-9. doi: 10.1111/j.1432-1033.1991.tb16062.x.
3
Effects of glucagon, dexamethasone and triiodothyronine on phosphoenolpyruvate carboxykinase (GTP) synthesis and mRNA level in rat liver cells.胰高血糖素、地塞米松和三碘甲状腺原氨酸对大鼠肝细胞中磷酸烯醇式丙酮酸羧激酶（GTP）合成及mRNA水平的影响。
Eur J Biochem. 1984 Dec 17;145(3):489-97. doi: 10.1111/j.1432-1033.1984.tb08583.x.
4
Regulation of gene expression in rat hepatocytes and hepatoma cells by insulin: quantitation of messenger ribonucleic acid's coding for tyrosine aminotransferase, tryptophan oxygenase, and phosphoenolpyruvate carboxykinase.胰岛素对大鼠肝细胞和肝癌细胞中基因表达的调控：酪氨酸转氨酶、色氨酸加氧酶和磷酸烯醇式丙酮酸羧激酶信使核糖核酸编码的定量分析
Endocrinology. 1986 Oct;119(4):1741-9. doi: 10.1210/endo-119-4-1741.
5
Regulation of phosphoenolpyruvate carboxykinase (GTP) synthesis in rat liver cells. Rapid induction of specific mRNA by glucagon or cyclic AMP and permissive effect of dexamethasone.大鼠肝细胞中磷酸烯醇式丙酮酸羧激酶（GTP）合成的调节。胰高血糖素或环磷酸腺苷对特异性mRNA的快速诱导作用以及地塞米松的允许效应。
J Biol Chem. 1982 Nov 25;257(22):13404-12.
6
The degradation of phosphoenopyruvate carboxykinase (GTP) mRNA is regulated by cyclic AMP but not by dexamethasone.磷酸烯醇丙酮酸羧激酶（GTP）信使核糖核酸的降解受环磷酸腺苷调控，而非地塞米松。
Arch Biochem Biophys. 1994 Jan;308(1):82-8. doi: 10.1006/abbi.1994.1012.
7
Development regulation of basal and hormone-inducible phosphoenolpyruvate carboxykinase gene expression in chick embryo liver in vivo.
Arch Biochem Biophys. 1994 Feb 15;309(1):10-7. doi: 10.1006/abbi.1994.1076.
8
Glucocorticoid-dependent induction of mRNA coding for phosphoenolpyruvate carboxykinase (GTP) in rat kidney. Its inhibition by cycloheximide.糖皮质激素依赖性诱导大鼠肾脏中磷酸烯醇式丙酮酸羧激酶（GTP）编码mRNA的表达。放线菌酮对其的抑制作用。
Eur J Biochem. 1980 Oct;111(1):89-98. doi: 10.1111/j.1432-1033.1980.tb06078.x.
9
Differential induction of transcription for glucocorticoid-responsive genes in cultured rat hepatocytes.培养的大鼠肝细胞中糖皮质激素反应性基因转录的差异诱导
Biochem Biophys Res Commun. 1990 Jan 15;166(1):133-8. doi: 10.1016/0006-291x(90)91921-e.
10
Regulation of messenger ribonucleic acid levels for five urea cycle enzymes in cultured rat hepatocytes. Requirements for cyclic adenosine monophosphate, glucocorticoids, and ongoing protein synthesis.培养的大鼠肝细胞中五种尿素循环酶信使核糖核酸水平的调节。环磷酸腺苷、糖皮质激素及持续蛋白质合成的需求。
Mol Endocrinol. 1988 May;2(5):444-51. doi: 10.1210/mend-2-5-444.

引用本文的文献

1
Down-regulation of rat mitochondrial branched-chain 2-oxoacid dehydrogenase kinase gene expression by glucocorticoids.糖皮质激素对大鼠线粒体支链2-氧代酸脱氢酶激酶基因表达的下调作用。
Biochem J. 1999 May 1;339 ( Pt 3)(Pt 3):503-10.
2
Glucocorticoid receptor, C/EBP, HNF3, and protein kinase A coordinately activate the glucocorticoid response unit of the carbamoylphosphate synthetase I gene.糖皮质激素受体、C/EBP、HNF3和蛋白激酶A协同激活氨甲酰磷酸合成酶I基因的糖皮质激素反应元件。
Mol Cell Biol. 1998 Nov;18(11):6305-15. doi: 10.1128/MCB.18.11.6305.
3
Transcriptional control of genes that regulate glycolysis and gluconeogenesis in adult liver.成年肝脏中调节糖酵解和糖异生的基因的转录调控。
Biochem J. 1994 Oct 1;303 ( Pt 1)(Pt 1):1-14. doi: 10.1042/bj3030001.
4
Cyclic AMP induces metallothionein gene expression in rat hepatocytes but not in rat kidney.环磷酸腺苷可诱导大鼠肝细胞中金属硫蛋白基因的表达，但对大鼠肾脏无此作用。
Biochem J. 1988 Oct 15;255(2):741-3.
5
Protein-synthesis-dependent induction of annexin I by glucocorticoid.糖皮质激素对膜联蛋白I的蛋白质合成依赖性诱导
Biochem J. 1991 Apr 15;275 ( Pt 2)(Pt 2):313-9. doi: 10.1042/bj2750313.

本文引用的文献

1
Glucocorticoid-dependent induction of mRNA coding for phosphoenolpyruvate carboxykinase (GTP) in rat kidney. Its inhibition by cycloheximide.糖皮质激素依赖性诱导大鼠肾脏中磷酸烯醇式丙酮酸羧激酶（GTP）编码mRNA的表达。放线菌酮对其的抑制作用。
Eur J Biochem. 1980 Oct;111(1):89-98. doi: 10.1111/j.1432-1033.1980.tb06078.x.
2
Gluconeogenesis in rat liver parenchymal cells in primary culture: permissive effect of the glucocorticoids on glucagon stimulation of gluconeogenesis.原代培养大鼠肝实质细胞中的糖异生作用：糖皮质激素对胰高血糖素刺激糖异生的允许作用
J Cell Physiol. 1981 Apr;107(1):11-9. doi: 10.1002/jcp.1041070103.
3
Effects of glucagon, dexamethasone and triiodothyronine on phosphoenolpyruvate carboxykinase (GTP) synthesis and mRNA level in rat liver cells.胰高血糖素、地塞米松和三碘甲状腺原氨酸对大鼠肝细胞中磷酸烯醇式丙酮酸羧激酶（GTP）合成及mRNA水平的影响。
Eur J Biochem. 1984 Dec 17;145(3):489-97. doi: 10.1111/j.1432-1033.1984.tb08583.x.
4
Ethanol modulation of the hormonal and nutritional regulation of glucose 6-phosphate dehydrogenase activity in primary cultures of rat hepatocytes.乙醇对大鼠肝细胞原代培养物中葡萄糖-6-磷酸脱氢酶活性的激素和营养调节的影响
Biochem J. 1984 Jan 15;217(2):543-9. doi: 10.1042/bj2170543.
5
Isolation and characterization of the gene coding for cytosolic phosphoenolpyruvate carboxykinase (GTP) from the rat.大鼠胞质磷酸烯醇式丙酮酸羧激酶（GTP）编码基因的分离与鉴定
Proc Natl Acad Sci U S A. 1983 Jun;80(12):3656-60. doi: 10.1073/pnas.80.12.3656.
6
Regulation of phosphoenolpyruvate carboxykinase (GTP) synthesis in rat liver cells. Rapid induction of specific mRNA by glucagon or cyclic AMP and permissive effect of dexamethasone.大鼠肝细胞中磷酸烯醇式丙酮酸羧激酶（GTP）合成的调节。胰高血糖素或环磷酸腺苷对特异性mRNA的快速诱导作用以及地塞米松的允许效应。
J Biol Chem. 1982 Nov 25;257(22):13404-12.
7
Glucagon and choleragen stimulation of glycogenolysis in primary cultures of adult rat liver parenchymal cells: lack of involvement of the glucocorticoids.胰高血糖素和霍乱毒素对成年大鼠肝实质细胞原代培养物中糖原分解的刺激作用：糖皮质激素未参与其中。
J Cell Physiol. 1982 Mar;110(3):304-10. doi: 10.1002/jcp.1041100314.
8
N6,O2'-dibutyryl cycle AMP and glucose regulate the amount of messenger RNA coding for hepatic phosphoenolpyruvate carboxykinase (GTP).N6,O2'-二丁酰环磷酸腺苷和葡萄糖调节编码肝磷酸烯醇式丙酮酸羧激酶（GTP）的信使核糖核酸的量。
J Biol Chem. 1982 Feb 25;257(4):2022-8.
9
Regulation of phosphoenolpyruvate carboxykinase (GTP) mRNA turnover in rat liver.大鼠肝脏中磷酸烯醇式丙酮酸羧激酶（GTP）mRNA 周转的调控
J Biol Chem. 1980 Sep 25;255(18):8509-15.
10
Phosphoenolpyruvate carboxykinase in cultured foetal hepatocytes from the rat. Ontogeny of hormone inducibility and role of glucocorticoids and insulin in enzyme induction.大鼠培养胎肝细胞中的磷酸烯醇式丙酮酸羧激酶。激素诱导的个体发生以及糖皮质激素和胰岛素在酶诱导中的作用。
Eur J Biochem. 1980 Feb;104(1):91-9. doi: 10.1111/j.1432-1033.1980.tb04404.x.

地塞米松在培养的大鼠肝细胞中诱导磷酸烯醇丙酮酸羧激酶（GTP）的mRNA生成需要持续的蛋白质合成。

Induction of mRNA for phosphoenolpyruvate carboxykinase (GTP) by dexamethasone in cultured rat hepatocytes requires on-going protein synthesis.

作者信息

Nebes V L, Morris S M

机构信息

Department of Microbiology, Biochemistry and Molecular Biology, University of Pittsburgh, PA 15261.

出版信息

Biochem J. 1987 Aug 15;246(1):237-40. doi: 10.1042/bj2460237.

DOI:10.1042/bj2460237
PMID:2823794
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1148264/
Abstract

Dexamethasone is necessary and sufficient to induce mRNA for phosphoenolpyruvate carboxykinase (GTP) (PEPCK) by 19-fold in rat hepatocytes cultured in serum-free medium. However, the time required for maximum induction is 16 h. The slow induction suggested that glucocorticoids regulate the expression of an intermediate gene product(s) which is required for glucocorticoid stimulation of PEPCK-gene expression. Consistent with this notion was the finding that cycloheximide completely blocked the response to dexamethasone. In contrast, cycloheximide did not block the response to a cyclic AMP analogue.

摘要

在无血清培养基中培养的大鼠肝细胞中，地塞米松足以使磷酸烯醇丙酮酸羧激酶（GTP）（PEPCK）的mRNA诱导19倍，且是必需的。然而，最大诱导所需时间为16小时。这种缓慢诱导表明糖皮质激素调节一种中间基因产物的表达，而该产物是糖皮质激素刺激PEPCK基因表达所必需的。与此观点一致的是，环己酰亚胺完全阻断了对地塞米松的反应。相反，环己酰亚胺并未阻断对环磷酸腺苷类似物的反应。