环磷酸腺苷可诱导大鼠肝细胞中金属硫蛋白基因的表达，但对大鼠肾脏无此作用。
Cyclic AMP induces metallothionein gene expression in rat hepatocytes but not in rat kidney.
作者信息
Nebes V L, DeFranco D, Morris S M
机构信息
Department of Microbiology, Biochemistry, and Molecular Biology, University of Pittsburgh, PA 15261.
出版信息
Biochem J. 1988 Oct 15;255(2):741-3.
Cyclic AMP analogues induced expression of metallothionein-I (MT-I) mRNA in adult rat liver and in rat hepatocytes cultured in serum-free medium. This induction occurred via an increased rate of transcription of the MT-I gene. The effect of cyclic AMP analogues was tissue-specific since no induction of MT-I mRNA occurred in rat kidney. Induction of MT-I mRNA by a combination of cyclic AMP analogue and dexamethasone was additive in liver and cultured hepatocytes, indicating that induction occurred via independent regulatory pathways.
环磷酸腺苷（cAMP）类似物可诱导成年大鼠肝脏及在无血清培养基中培养的大鼠肝细胞中金属硫蛋白-I（MT-I）信使核糖核酸（mRNA）的表达。这种诱导是通过MT-I基因转录速率的增加而发生的。cAMP类似物的作用具有组织特异性，因为在大鼠肾脏中未发生MT-I mRNA的诱导。在肝脏和培养的肝细胞中，cAMP类似物与地塞米松联合使用对MT-I mRNA的诱导作用是相加的，这表明诱导是通过独立的调节途径发生的。
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