铜绿假单胞菌的III型分泌系统：通过注射进行感染。
The type III secretion system of Pseudomonas aeruginosa: infection by injection.
作者信息
Hauser Alan R
机构信息
Departments of MicrobiologyImmunology and Medicine, Northwestern University, Chicago, Illinois 60611, USA.
出版信息
Nat Rev Microbiol. 2009 Sep;7(9):654-65. doi: 10.1038/nrmicro2199.
Abstract
The Gram-negative bacterium Pseudomonas aeruginosa uses a complex type III secretion apparatus to inject effector proteins into host cells. The configuration of this secretion machinery, the activities of the proteins that are injected by it and the consequences of this process for infection are now being elucidated. This Review summarizes our current knowledge of P. aeruginosa type III secretion, including the secretion and translocation machinery, the regulation of this machinery, and the associated chaperones and effector proteins. The features of this interesting secretion system have important implications for the pathogenesis of P. aeruginosa infections and for other type III secretion systems.
摘要
革兰氏阴性菌铜绿假单胞菌利用一种复杂的III型分泌装置将效应蛋白注入宿主细胞。目前正在阐明这种分泌机制的结构、由其注入的蛋白质的活性以及这一过程对感染的影响。本综述总结了我们目前对铜绿假单胞菌III型分泌的认识，包括分泌和转运机制、该机制的调控以及相关的分子伴侣和效应蛋白。这个有趣的分泌系统的特点对铜绿假单胞菌感染的发病机制以及其他III型分泌系统具有重要意义。
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