Yu Xiao-Quan, Gong Yu-Wen, Tian Jun-Qiang, Peng Cheng, Niu Shao-Min, Feng Han-Zhong, You Chong-Ge, Wang Zhi-Ping
Institute of Urology, Gansu Province Clinical Research Center for urinary system disease, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, 730030, Gansu, People's Republic of China.
Laboratory Medicine Center, The Second Hospital of Lanzhou University, Lanzhou, 730030, Gansu, People's Republic of China.
World J Urol. 2025 Jun 20;43(1):380. doi: 10.1007/s00345-025-05758-3.
Pseudomonas aeruginosa, a key member of the ESKAPE pathogen group, is a common cause of urinary tract infections (UTIs), particularly in patients with indwelling urinary catheters. Due to its large genome, P. aeruginosa has a high potential for genetic mutations, enabling the development of multidrug resistance. Additionally, it produces a variety of virulence factors, which contribute to persistent and often refractory infections. While UTIs caused by Escherichia coli have been extensively studied, those caused by P. aeruginosa remain less well understood. Understanding the mechanisms underlying the occurrence and progression of P. aeruginosa-associated UTIs, as well as the evolution of its antimicrobial resistance, is crucial for developing more effective treatment strategies. This paper provides an overview of the interaction between P. aeruginosa and UTIs, offering insights that could aid in more effective management and eradication of P. aeruginosa in the urinary tract.
铜绿假单胞菌是ESKAPE病原体组的关键成员，是尿路感染（UTI）的常见病因，尤其是在留置导尿管的患者中。由于其基因组庞大，铜绿假单胞菌具有很高的基因突变潜力，能够产生多重耐药性。此外，它还产生多种毒力因子，这些因子导致持续性且往往难以治愈的感染。虽然由大肠杆菌引起的尿路感染已得到广泛研究，但由铜绿假单胞菌引起的尿路感染仍了解较少。了解铜绿假单胞菌相关尿路感染的发生和进展机制及其抗菌耐药性的演变，对于制定更有效的治疗策略至关重要。本文概述了铜绿假单胞菌与尿路感染之间的相互作用，提供了有助于更有效地管理和根除尿路中铜绿假单胞菌的见解。
