Yamamoto Ryohei, Imai Enyu
Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan.
Kidney Int. 2009 Sep;76(5):477-80. doi: 10.1038/ki.2009.206.
IgA nephropathy is a common glomerulonephritis. About 30% of patients develop end-stage kidney disease within 20 years. A strategy for predicting prognosis from biopsy-based pathological evaluation has not been well established because of lack of reproducibility and inappropriate categorization. The new Oxford classification of IgA nephropathy provides a histopathological grading system with reproducibility for prediction of renal prognosis of IgA nephropathy independent of the clinical features. The classification must be validated in the different cohorts.
IgA肾病是一种常见的肾小球肾炎。约30%的患者在20年内发展为终末期肾病。由于缺乏可重复性和分类不当，基于活检的病理评估预测预后的策略尚未得到很好的确立。IgA肾病的新牛津分类提供了一种具有可重复性的组织病理学分级系统，用于独立于临床特征预测IgA肾病的肾脏预后。该分类必须在不同队列中进行验证。
