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新月柄杆菌不对称细胞分裂周期的时间控制

Temporal controls of the asymmetric cell division cycle in Caulobacter crescentus.

作者信息

Li Shenghua, Brazhnik Paul, Sobral Bruno, Tyson John J

机构信息

Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.

出版信息

PLoS Comput Biol. 2009 Aug;5(8):e1000463. doi: 10.1371/journal.pcbi.1000463. Epub 2009 Aug 14.

DOI:10.1371/journal.pcbi.1000463
PMID:19680425
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2714070/
Abstract

The asymmetric cell division cycle of Caulobacter crescentus is orchestrated by an elaborate gene-protein regulatory network, centered on three major control proteins, DnaA, GcrA and CtrA. The regulatory network is cast into a quantitative computational model to investigate in a systematic fashion how these three proteins control the relevant genetic, biochemical and physiological properties of proliferating bacteria. Different controls for both swarmer and stalked cell cycles are represented in the mathematical scheme. The model is validated against observed phenotypes of wild-type cells and relevant mutants, and it predicts the phenotypes of novel mutants and of known mutants under novel experimental conditions. Because the cell cycle control proteins of Caulobacter are conserved across many species of alpha-proteobacteria, the model we are proposing here may be applicable to other genera of importance to agriculture and medicine (e.g., Rhizobium, Brucella).

摘要

新月柄杆菌的不对称细胞分裂周期由一个精心构建的基因-蛋白质调控网络协调，该网络以三种主要调控蛋白DnaA、GcrA和CtrA为核心。这个调控网络被构建成一个定量计算模型，以便系统地研究这三种蛋白质如何控制增殖细菌的相关遗传、生化和生理特性。数学模型中体现了对游动细胞和柄细胞周期的不同调控。该模型通过野生型细胞和相关突变体的观察表型进行验证，并预测新突变体以及已知突变体在新实验条件下的表型。由于柄杆菌的细胞周期调控蛋白在许多α-变形菌物种中是保守的,我们在此提出的模型可能适用于对农业和医学具有重要意义的其他属（例如，根瘤菌属、布鲁氏菌属）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cb6/2714070/c33ceb88d3d7/pcbi.1000463.g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cb6/2714070/3bd15df3c411/pcbi.1000463.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cb6/2714070/f59aa12ca671/pcbi.1000463.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cb6/2714070/ad9335234df5/pcbi.1000463.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cb6/2714070/5c77e411c50a/pcbi.1000463.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cb6/2714070/1cb2f0f62b40/pcbi.1000463.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cb6/2714070/600b1559cbf8/pcbi.1000463.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cb6/2714070/cacd3d696afa/pcbi.1000463.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cb6/2714070/6addc8ee3907/pcbi.1000463.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cb6/2714070/0c0bea41a5e5/pcbi.1000463.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cb6/2714070/a2e3a1f780da/pcbi.1000463.g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cb6/2714070/68a5d95d5c36/pcbi.1000463.g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cb6/2714070/37bfc53836f7/pcbi.1000463.g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cb6/2714070/c33ceb88d3d7/pcbi.1000463.g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cb6/2714070/3bd15df3c411/pcbi.1000463.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cb6/2714070/f59aa12ca671/pcbi.1000463.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cb6/2714070/ad9335234df5/pcbi.1000463.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cb6/2714070/5c77e411c50a/pcbi.1000463.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cb6/2714070/1cb2f0f62b40/pcbi.1000463.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cb6/2714070/600b1559cbf8/pcbi.1000463.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cb6/2714070/cacd3d696afa/pcbi.1000463.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cb6/2714070/6addc8ee3907/pcbi.1000463.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cb6/2714070/0c0bea41a5e5/pcbi.1000463.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cb6/2714070/a2e3a1f780da/pcbi.1000463.g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cb6/2714070/68a5d95d5c36/pcbi.1000463.g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cb6/2714070/37bfc53836f7/pcbi.1000463.g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cb6/2714070/c33ceb88d3d7/pcbi.1000463.g013.jpg

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