Bonde B G, Privalsky M L
Department of Microbiology, University of California, Davis 95616.
J Virol. 1990 Mar;64(3):1314-20. doi: 10.1128/JVI.64.3.1314-1320.1990.
The v-erbA oncogene, a transduced copy of a thyroid hormone receptor, plays an important role in establishment of the transformed cell phenotype induced by avian erythroblastosis virus. The ability of thyroid hormone receptors to bind to specific sites on chromatin and to thereby modify the expression of adjacent target genes is a crucial element in their mechanism of action in the normal cell. The v-erbA protein also bound at high affinity to a set of DNA fragments recognized by the rat thyroid hormone receptor, but the relative affinity of the v-erbA protein for the different binding sites was distinct from that previously reported for the thyroid hormone receptors.
v-erbA癌基因是甲状腺激素受体的转导拷贝，在禽成红细胞增多症病毒诱导的转化细胞表型的建立中起重要作用。甲状腺激素受体与染色质上特定位点结合并由此改变相邻靶基因表达的能力是其在正常细胞中作用机制的关键要素。v-erbA蛋白也以高亲和力结合到一组被大鼠甲状腺激素受体识别的DNA片段上，但v-erbA蛋白对不同结合位点的相对亲和力与先前报道的甲状腺激素受体不同。
