Xu Xiao, Zhu Lingyi, Tang Yu, Wang Yi, Zhang Ken, Li Sarah, Bohman Lisa C, Gerlach Robert W
School of Medicine, No. 9 People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Am J Dent. 2007 Sep;20 Spec No A:28A-31A.
To evaluate efficacy and safety of peroxide-containing whitening strips and a paint-on gel relative to a non-peroxide experimental control.
After informed consent, 52 healthy adults in Shanghai, China were randomized to one of three treatment groups: 6% hydrogen peroxide whitening strips (Crest Whitestrips), 5.9% hydrogen peroxide paint-on gel (Colgate Simply White), or water rinse which served as a negative experimental control. Strip use was twice daily over 7 days, while the paint-on gel and rinse were used twice daily over 14 days. Efficacy was measured from standard digital images of the maxillary anterior teeth, and safety was assessed from interview and intraoral examination.
Whitening strips provided the greatest end-of-treatment reduction in yellowness (Deltab*), with adjusted means +/- standard errors of -1.72 +/- 0.18 for the strip group, -0.48 +/- 0.10 for the paint-on gel group, and 0.13 +/- 0.09 for the water rinse group. For DeltaL* (lightness), end-of-treatment adjusted means +/- standard errors were 1.88 +/- 0.21 for the strip group, 0.60 +/- 0.15 for the paint-on gel, and -0.10 +/- 0.18 for the negative control. Groups differed significantly (P< 0.007) with respect to Deltab* and DeltaL* at end-of-treatment, as well as other color parameters. All treatments were well-tolerated.
评估含过氧化物的美白牙贴和涂抹式凝胶相对于无过氧化物的实验对照物的有效性和安全性。
在获得知情同意后，中国上海的52名健康成年人被随机分为三个治疗组之一：6%过氧化氢美白牙贴（佳洁士美白牙贴）、5.9%过氧化氢涂抹式凝胶（高露洁亮白牙胶）或清水冲洗作为阴性实验对照。牙贴每天使用两次，持续7天，而涂抹式凝胶和冲洗液每天使用两次，持续14天。通过上颌前牙的标准数字图像测量疗效，并通过访谈和口腔检查评估安全性。
美白牙贴在治疗结束时使牙齿黄度降低最多（Δb*），牙贴组调整后的均值±标准误为-1.72±0.18，涂抹式凝胶组为-0.48±0.10，清水冲洗组为0.13±0.09。对于ΔL*（亮度），治疗结束时调整后的均值±标准误，牙贴组为1.88±0.21，涂抹式凝胶组为0.60±0.15，阴性对照组为-0.10±0.18。在治疗结束时，各组在Δb和ΔL以及其他颜色参数方面存在显著差异（P<0.007）。所有治疗耐受性良好。
