Yudhira Rafael, Peumans Marleen, Barker Matthew L, Gerlach Robert W
Catholic University of Leuven, Departement Tandheelkunde, Mondziekten en Kaakchirurgie, UZ Sint-Rafael, Leuven, Belgium.
Am J Dent. 2007 Sep;20 Spec No A:32A-36A.
To compare tooth whitening with 6% hydrogen peroxide whitening strips and two whitening dentifrices in a 12-week randomized controlled trial at a Belgian dental school.
After informed consent, 46 healthy adults were randomly assigned to one of three strip + dentifrice treatment groups. Subjects received either 6% hydrogen peroxide whitening strips (Crest Whitestrips) and an anticavity toothpaste (Crest Cavity Protection), placebo strips and a sodium fluoride (NaF) whitening dentifrice (Mentadent Whitening Toothpaste) or placebo strips and a sodium monofluorophosphate (MFP) whitening dentifrice (Rembrandt Low Abrasion Whitening Toothpaste). Strip use (peroxide or placebo) was for 30 minutes, twice daily for 2 weeks, while dentifrice use was at least twice daily for 12 weeks. Efficacy was measured from standardized digital images of the maxillary facial tooth surfaces, while safety was evaluated from oral examination and interview. Treatments were compared after 2 weeks (strip use) and 12 weeks (dentifrice use) using analysis of covariance.
All subjects completed the 12-week evaluation. Adjusting for baseline and age, the peroxide strip group had -2.45 Deltab*, 2.39 DeltaL*, and -0.96 Deltaa* at Week 2. Between-group comparisons demonstrated significant (P< 0.0001) reductions in yellowness and redness, and increased brightness favoring the peroxide strip group. The peroxide strip group demonstrated 95%+ color retention (Deltab* & DeltaL*) at Week 12, differing significantly (P< 0.0001) versus either of the continuously used whitening dentifrices. There were no significant (P> 0.18) differences between the whitening dentifrice groups at any timepoints. All treatments were well-tolerated, with minor tooth sensitivity and oral irritation representing the most common findings.
在比利时一所牙科学校进行的一项为期12周的随机对照试验中，比较6%过氧化氢美白牙贴与两种美白牙膏的牙齿美白效果。
在获得知情同意后，46名健康成年人被随机分配到三个牙贴+牙膏治疗组中的一组。受试者分别接受6%过氧化氢美白牙贴（佳洁士美白牙贴）和防蛀牙膏（佳洁士防蛀牙膏）、安慰剂牙贴和含氟（NaF）美白牙膏（门达顿美白牙膏）或安慰剂牙贴和单氟磷酸钠（MFP）美白牙膏（伦勃朗低磨损美白牙膏）。使用牙贴（过氧化氢或安慰剂）30分钟，每天两次，持续2周，而使用牙膏至少每天两次，持续12周。通过上颌面部牙齿表面的标准化数字图像测量疗效，同时通过口腔检查和访谈评估安全性。使用协方差分析在2周（使用牙贴后）和12周（使用牙膏后）比较治疗效果。
所有受试者均完成了12周的评估。在调整基线和年龄后，过氧化氢牙贴组在第2周时的Δb为-2.45、ΔL为2.39、Δa为-0.96。组间比较显示，与其他组相比，过氧化氢牙贴组的黄度和红度显著降低（P<0.0001），亮度增加。过氧化氢牙贴组在第12周时的颜色保留率达到95%以上（Δb和ΔL*），与持续使用的任何一种美白牙膏相比均有显著差异（P<0.0001）。在任何时间点，美白牙膏组之间均无显著差异（P>0.18）。所有治疗耐受性良好，最常见的情况是轻微的牙齿敏感和口腔刺激。
