Li Olive Tw, Poon Leo Lm
Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China.
Expert Rev Anti Infect Ther. 2009 Aug;7(6):687-90. doi: 10.1586/eri.09.48.
Evaluation of: Sui J, Hwang WC, Perez S et al. Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses. Nat. Struct. Mol. Biol. 16(3), 265-273 (2009). The continuous antigenic drifts and occasional antigenic shifts enable human influenza viruses to escape the human immune system. Moreover, the frequent occurrence of human H5N1-infected cases and the recent emergency of a novel swine-like human H1N1 influenza virus further reiterate the risk of the introduction of a new pandemic strain to humans through in toto transfer of an animal influenza virus. The discovery of neutralizing antibodies that are broadly reactive with multiple influenza subtypes is therefore extremely important for the influenza pandemic preparedness, for use either for therapeutic purposes or as the basis of vaccine development. Here, we review some of the recent developments in this area.
隋杰、黄维成、佩雷斯等人。禽甲型流感病毒和人甲型流感病毒广谱中和的结构与功能基础。《自然·结构与分子生物学》16(3)，265 - 273(2009年)。人类流感病毒持续的抗原漂移和偶尔的抗原转变使其能够逃避人体免疫系统。此外，人感染H5N1病例的频繁出现以及新型猪源样人H1N1流感病毒的近期出现，进一步凸显了动物流感病毒通过完全转移给人类而引入新的大流行毒株的风险。因此，发现能与多种流感亚型广泛反应的中和抗体对于流感大流行防范极为重要，可用于治疗目的或作为疫苗研发的基础。在此，我们综述该领域的一些最新进展。
