人粒细胞无形体病、人单核细胞埃立克体病和尤因埃立克体病的当前管理
Current management of human granulocytic anaplasmosis, human monocytic ehrlichiosis and Ehrlichia ewingii ehrlichiosis.
作者信息
Thomas Rachael J, Dumler J Stephen, Carlyon Jason A
机构信息
Department of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
出版信息
Expert Rev Anti Infect Ther. 2009 Aug;7(6):709-22. doi: 10.1586/eri.09.44.
Abstract
Anaplasma phagocytophilum, Ehrlichia chaffeensis and Ehrlichia ewingii are emerging tick-borne pathogens and are the causative agents of human granulocytic anaplasmosis, human monocytic ehrlichiosis and E. ewingii ehrlichiosis, respectively. Collectively, these are referred to as human ehrlichioses. These obligate intracellular bacterial pathogens of the family Anaplasmataceae are transmitted by Ixodes spp. or Amblyomma americanum ticks and infect peripherally circulating leukocytes to cause infections that range in clinical spectra from asymptomatic seroconversion to mild, severe or, in rare instances, fatal disease. This review describes: the ecology of each pathogen; the epidemiology, clinical signs and symptoms of the human diseases that each causes; the choice methods for diagnosing and treating human ehrlichioses; recommendations for patient management; and is concluded with suggestions for potential future research.
摘要
嗜吞噬细胞无形体、查菲埃立克体和尤因埃立克体是新出现的蜱传病原体，分别是人类粒细胞无形体病、人类单核细胞埃立克体病和尤因埃立克体病的病原体。这些疾病统称为人类埃立克体病。这些无形体科专性细胞内细菌病原体由硬蜱属或美洲钝眼蜱传播，感染外周循环白细胞，导致的感染临床谱范围从无症状血清转化到轻度、重度，或在罕见情况下导致致命疾病。本综述描述了：每种病原体的生态学；每种病原体所致人类疾病的流行病学、临床体征和症状；诊断和治疗人类埃立克体病的选择方法；患者管理建议；并以对未来潜在研究的建议作为总结。
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