Lestner Jodi M, Roberts Steven A, Moore Caroline B, Howard Susan J, Denning David W, Hope William W
The University of Manchester, Manchester Academic Health Science Centre, NIHR Translational Research Facility in Respiratory Medicine, University Hospital of South Manchester NHS Foundation Trust, Manchester, UK.
Clin Infect Dis. 2009 Sep 15;49(6):928-30. doi: 10.1086/605499.
We explored concentration-toxicity relationships for itraconazole among 216 patients. Logistic regression revealed a progressive increase in the probability of toxicity with increasing concentrations of itraconazole. Classification and regression tree analysis suggested that 17.1 mg/L of itraconazole (measured using a bioassay) was the concentration level at which the population of patients was separated into 2 groups, each with a high and a low probability of toxicity.
我们在216名患者中探究了伊曲康唑的浓度-毒性关系。逻辑回归显示，随着伊曲康唑浓度的增加，毒性发生概率呈逐步上升趋势。分类与回归树分析表明，伊曲康唑浓度为17.1 mg/L（采用生物测定法测量）时，患者群体被分为两组，每组发生毒性的概率有高有低。
