Artificial Organs Laboratory, Department of Surgery, University of Maryland School of Medicine, 10. S. Pine Street, Baltimore, MD 21201, USA.
Artif Organs. 2009 Oct;33(10):805-17. doi: 10.1111/j.1525-1594.2009.00807.x. Epub 2009 Jul 22.
For the need for respiratory support for patients with acute or chronic lung diseases to be addressed, a novel integrated maglev pump-oxygenator (IMPO) is being developed as a respiratory assist device. IMPO was conceptualized to combine a magnetically levitated pump/rotor with uniquely configured hollow fiber membranes to create an assembly-free, ultracompact system. IMPO is a self-contained blood pump and oxygenator assembly to enable rapid deployment for patients requiring respiratory support or circulatory support. In this study, computational fluid dynamics (CFD) and computer-aided design were conducted to design and optimize the hemodynamics, gas transfer, and hemocompatibility performances of this novel device. In parallel, in vitro experiments including hydrodynamic, gas transfer, and hemolysis measurements were conducted to evaluate the performance of IMPO. Computational results from CFD analysis were compared with experimental data collected from in vitro evaluation of the IMPO. The CFD simulation demonstrated a well-behaved and streamlined flow field in the main components of this device. The results of hydrodynamic performance, oxygen transfer, and hemolysis predicted by computational simulation, along with the in vitro experimental data, indicate that this pump-lung device can provide the total respiratory need of an adult with lung failure, with a low hemolysis rate at the targeted operating condition. These detailed CFD designs and analyses can provide valuable guidance for further optimization of this IMPO for long-term use.
为了解决急性或慢性肺部疾病患者对呼吸支持的需求，我们正在开发一种新型集成磁悬浮泵-氧合器（IMPO）作为呼吸辅助设备。IMPO 的设计理念是将磁悬浮泵/转子与独特配置的中空纤维膜结合在一起，以创建一个无组件、超紧凑的系统。IMPO 是一个独立的血液泵和氧合器组件，可快速部署给需要呼吸或循环支持的患者。在这项研究中，我们进行了计算流体动力学（CFD）和计算机辅助设计，以设计和优化这种新型装置的血液动力学、气体传递和血液相容性性能。同时，还进行了包括水动力、气体传递和溶血测量在内的体外实验，以评估 IMPO 的性能。CFD 分析的计算结果与从 IMPO 的体外评估中收集的实验数据进行了比较。CFD 模拟显示该装置主要部件中的流场表现良好且流线型。计算模拟预测的水动力性能、氧气传递和溶血结果，以及体外实验数据表明，这种泵-肺装置可以满足肺功能衰竭的成人的全部呼吸需求，在目标工作条件下具有较低的溶血率。这些详细的 CFD 设计和分析可为进一步优化该 IMPO 以实现长期使用提供有价值的指导。
