Department of Dentistry, University of Granada, Granada, Spain.
Clin Implant Dent Relat Res. 2011 Dec;13(4):262-8. doi: 10.1111/j.1708-8208.2009.00211.x. Epub 2009 Aug 3.
The aim of this study was to evaluate the effect of the topical application of melatonin on osteointegration of dental implants in Beagle dogs 5 and 8 weeks after their insertion.
For subsequent insertion of dental implants, upper and lower premolars and molars were extracted from 12 Beagle dogs. Each mandible received cylindrical screw implants of 3.25 mm in diameter and 10 mm in length. The implants were randomly assigned to the mesial and distal sites on each side of the mandible. Prior to implanting, 1.2 mg lyophylized powder melatonin was applied to one bone hole at each side of the mandible. None was applied at the control sites. Eight histological sections per implant were obtained for histomorphometric studies.
After 5- and 8-week treatment periods, melatonin significantly increased the inter-thread bone (p < 0.05) and new bone formation (p < 0.05) in comparison to control implants in both weeks. There were no significant increases in the bone-to-implant contact and peri-implant bone (p > 0.05).
Topical application of melatonin may act as a biomimetic agent in the placement of endo-osseous dental implants at 5 and 8 weeks after the implantation.
本研究旨在评估在犬牙植入物植入后 5 周和 8 周时，局部应用褪黑素对其骨整合的影响。
为了后续植入牙种植体，从 12 只比格犬中拔出上、下前磨牙和磨牙。每只下颌骨接受直径为 3.25 毫米、长度为 10 毫米的圆柱形螺丝种植体。将种植体随机分配到下颌骨两侧的近中和远中部位。在植入前，将 1.2 毫克冻干褪黑素粉末应用于下颌骨每侧的一个骨孔。对照部位不应用。每个种植体获得 8 个组织学切片进行组织形态计量学研究。
在 5 周和 8 周的治疗期后，与对照组相比，褪黑素显著增加了螺纹间骨（p<0.05）和新骨形成（p<0.05）。骨-种植体接触和种植体周围骨没有显著增加（p>0.05）。
局部应用褪黑素可能在植入后 5 周和 8 周时作为一种仿生剂，作用于骨内种植体的放置。
