Department of Special Care in Dentistry, School of Dentistry, University of Granada, Granada, Spain.
Int J Oral Maxillofac Implants. 2009 Nov-Dec;24(6):1068-73.
The aim of this study was to evaluate the effect of the topical application of growth hormone on the osseointegration of dental implants in beagle dogs 14 days after placement.
Maxillary and mandibular premolars and molars were extracted from 12 beagle dogs. Two months later, each mandible received cylindric screw-type implants of 3.25 mm in diameter and 10 mm in length. The implants were randomly assigned to the mesial and distal sites on each side of the mandible. Prior to implantation, lyophilized powdered growth hormone was applied to one osteotomy on each side of the mandible. No growth hormone was applied at the control sites. Eight histologic sections per implant were obtained for histomorphometric analysis.
After a 2-week treatment period, the growth hormone-treated sites showed significant (P < .0001) increases in the perimeter of bone that was in direct contact with the treated implants (40.19% +/- 2.51%), total peri-implant area (P < .001) (69.57% +/- 3.53%), and new bone formation (P < .0001) (35.18% +/- 0.31%), in comparison to control implants (25.05% +/- 2.43%, 53.40% +/- 4.58%, and 28.65% +/- 1.92%, respectively). There was no significant increase in interthread bone in growth hormone-treated implants (27.92% +/- 3.31%) in comparison to control implants (25.08% +/- 3.47%) (P > .05).
Topical application of growth hormone may act as a bone stimulant in the placement of endosseous dental implants.
本研究旨在评估生长激素局部应用对种植体植入后 14 天犬牙骨整合的影响。
12 只比格犬拔除上颌和下颌前磨牙及磨牙。2 个月后，每只下颌骨接受 3.25mm 直径和 10mm 长度的圆柱形螺纹式种植体。种植体随机分配到下颌骨每侧的近中和远中位点。在植入前，将冻干粉末状生长激素应用于下颌骨每侧的一个骨切开部位。在对照部位不应用生长激素。每个种植体获得 8 个组织学切片进行组织形态计量学分析。
经过 2 周的治疗期，生长激素处理部位与处理种植体直接接触的骨周径显著增加（P <.0001）（40.19% +/- 2.51%），总种植体周围面积（P <.001）（69.57% +/- 3.53%）和新骨形成（P <.0001）（35.18% +/- 0.31%），与对照种植体相比（分别为 25.05% +/- 2.43%、53.40% +/- 4.58%和 28.65% +/- 1.92%）。与对照种植体（27.92% +/- 3.31%）相比，生长激素处理种植体的螺纹间骨无明显增加（25.08% +/- 3.47%）（P >.05）。
生长激素局部应用可能作为骨刺激剂促进骨内牙种植体的植入。
