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Single-cycle replicable Rift Valley fever virus mutants as safe vaccine candidates.单周期可复制的裂谷热病毒突变体作为安全的候选疫苗
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本文引用的文献

1
The αGal HyperAcute(®) Technology: enhancing immunogenicity of antiviral vaccines by exploiting the natural αGal-mediated zoonotic blockade.αGal 超敏（®）技术：利用天然的αGal 介导的人畜共患病阻断作用增强抗病毒疫苗的免疫原性。
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Mechanism for increased immunogenicity of vaccines that form in vivo immune complexes with the natural anti-Gal antibody.与天然抗Gal抗体在体内形成免疫复合物的疫苗免疫原性增强的机制。
Vaccine. 2009 May 18;27(23):3072-82. doi: 10.1016/j.vaccine.2009.03.019. Epub 2009 Mar 28.
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T-705 (favipiravir) and related compounds: Novel broad-spectrum inhibitors of RNA viral infections.T-705（法匹拉韦）及相关化合物：新型RNA病毒感染的广谱抑制剂。
Antiviral Res. 2009 Jun;82(3):95-102. doi: 10.1016/j.antiviral.2009.02.198. Epub 2009 Mar 6.
4
NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinase.裂谷热病毒的NSs蛋白诱导双链RNA依赖性蛋白激酶的特异性降解。
J Virol. 2009 May;83(9):4365-75. doi: 10.1128/JVI.02148-08. Epub 2009 Feb 11.
5
Rift Valley fever virus NSs protein promotes post-transcriptional downregulation of protein kinase PKR and inhibits eIF2alpha phosphorylation.裂谷热病毒NSs蛋白促进蛋白激酶PKR的转录后下调并抑制eIF2α磷酸化。
PLoS Pathog. 2009 Feb;5(2):e1000287. doi: 10.1371/journal.ppat.1000287. Epub 2009 Feb 6.
6
Potential for North American mosquitoes to transmit Rift Valley fever virus.北美蚊子传播裂谷热病毒的可能性。
J Am Mosq Control Assoc. 2008 Dec;24(4):502-7. doi: 10.2987/08-5791.1.
7
An alphavirus replicon-derived candidate vaccine against Rift Valley fever virus.一种源自甲病毒复制子的裂谷热病毒候选疫苗。
Epidemiol Infect. 2009 Sep;137(9):1309-18. doi: 10.1017/S0950268808001696. Epub 2009 Jan 27.
8
Vaccination with virus-like particles protects mice from lethal infection of Rift Valley Fever Virus.用病毒样颗粒进行疫苗接种可保护小鼠免受裂谷热病毒的致死性感染。
Virology. 2009 Mar 15;385(2):409-15. doi: 10.1016/j.virol.2008.12.012. Epub 2009 Jan 20.
9
Efficient production of Rift Valley fever virus-like particles: The antiviral protein MxA can inhibit primary transcription of bunyaviruses.裂谷热病毒样颗粒的高效生产：抗病毒蛋白MxA可抑制布尼亚病毒的初级转录。
Virology. 2009 Mar 15;385(2):400-8. doi: 10.1016/j.virol.2008.12.011. Epub 2009 Jan 19.
10
Characterisation of immune responses and protective efficacy in mice after immunisation with Rift Valley Fever virus cDNA constructs.用裂谷热病毒cDNA构建体免疫小鼠后免疫反应及保护效力的表征
Virol J. 2009 Jan 17;6:6. doi: 10.1186/1743-422X-6-6.

裂谷热病毒的反向遗传学技术：治疗方法和疫苗开发的当前及未来应用

Reverse genetics technology for Rift Valley fever virus: current and future applications for the development of therapeutics and vaccines.

作者信息

Bouloy Michele, Flick Ramon

机构信息

Institut Pasteur, Unité de Génétique Moléculaire des Bunyavirus, Paris Cedex, France.

出版信息

Antiviral Res. 2009 Nov;84(2):101-18. doi: 10.1016/j.antiviral.2009.08.002. Epub 2009 Aug 12.

DOI:10.1016/j.antiviral.2009.08.002
PMID:19682499
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2801414/
Abstract

The advent of reverse genetics technology has revolutionized the study of RNA viruses, making it possible to manipulate their genomes and evaluate the effects of these changes on their biology and pathogenesis. The fundamental insights gleaned from reverse genetics-based studies over the last several years provide a new momentum for the development of designed therapies for the control and prevention of these viral pathogens. This review summarizes the successes and stumbling blocks in the development of reverse genetics technologies for Rift Valley fever virus and their application to the further dissection of its pathogenesis and the design of new therapeutics and safe and effective vaccines.

摘要

反向遗传学技术的出现彻底改变了RNA病毒的研究，使得操纵其基因组并评估这些变化对其生物学特性和发病机制的影响成为可能。过去几年基于反向遗传学的研究所获得的基本见解为开发用于控制和预防这些病毒病原体的设计疗法提供了新的动力。本综述总结了裂谷热病毒反向遗传学技术开发过程中的成功与障碍，以及这些技术在进一步剖析其发病机制、设计新疗法和安全有效的疫苗方面的应用。