Battiston Bruno, Raimondo Stefania, Tos Pierluigi, Gaidano Valentina, Audisio Chiara, Scevola Anna, Perroteau Isabelle, Geuna Stefano
Reconstructive Microsurgery Unit, Department of Orthopedics, C.T.O. Hospital, Turin 10126, Italy.
Int Rev Neurobiol. 2009;87:227-49. doi: 10.1016/S0074-7742(09)87011-6.
Tissue engineering of peripheral nerves has seen an increasing interest over the last years and, similarly to many other fields of regenerative medicine, great expectations have risen within the general public to its potential clinical application in the treatment of damaged nerves. However, in spite of the scientific advancements, applications to the patients is still very limited and it appears that to optimize the strategy for the tissue engineering of the peripheral nerves in the clinical view, researchers have to strive for a new level of innovation which will bring together (in a multitranslational approach) the main pillars of tissue engineering: namely (1) microsurgery, (2) cell and tissue transplantation, (3) material science, and (4) gene transfer. This review paper provides an overview of these four key approaches to peripheral nerve tissue engineering. While some of these issues will also be specifically addressed in other papers in this special issue on peripheral nerve regeneration of the International Review of Neurobiology, in this paper we will focus on an example of successful translational research in tissue engineering, namely nerve reconstruction by muscle-vein-combined nerve scaffolds.
在过去几年中，周围神经组织工程越来越受到关注，与再生医学的许多其他领域一样，公众对其在受损神经治疗中的潜在临床应用寄予厚望。然而，尽管有科学进展，但在患者中的应用仍然非常有限，并且从临床角度来看，为了优化周围神经组织工程策略，研究人员必须努力达到一个新的创新水平，这将（以多转化方法）汇集组织工程的主要支柱：即（1）显微外科手术，（2）细胞和组织移植，（3）材料科学，以及（4）基因转移。本文综述了周围神经组织工程的这四种关键方法。虽然其中一些问题也将在《国际神经生物学评论》关于周围神经再生的这一特刊的其他论文中具体讨论，但在本文中，我们将重点关注组织工程中成功的转化研究实例，即通过肌肉 - 静脉联合神经支架进行神经重建。
