Caillaud Martial, Richard Laurence, Vallat Jean-Michel, Desmoulière Alexis, Billet Fabrice
University of Limoges, Myelin Maintenance and Peripheral Neuropathies, Faculties of Medicine and Pharmacy, Limoges, France.
University Hospital of Limoges, Department of Neurology, "Reference Center for Rare Peripheral Neuropathies", Department of Neurology, Limoges, France.
Neural Regen Res. 2019 Jan;14(1):24-33. doi: 10.4103/1673-5374.243699.
Peripheral nerves are particularly vulnerable to injuries and are involved in numerous pathologies for which specific treatments are lacking. This review summarizes the pathophysiological features of the most common traumatic nerve injury in humans and the different animal models used in nerve regeneration studies. The current knowledge concerning Wallerian degeneration and nerve regrowth is then described. Finally, the involvement of intraneural vascularization in these processes is addressed. As intraneural vascularization has been poorly studied, histological experiments were carried out from rat sciatic nerves damaged by a glycerol injection. The results, taken together with the data from literature, suggest that revascularization plays an important role in peripheral nerve regeneration and must therefore be studied more carefully.
周围神经特别容易受到损伤，并且涉及许多缺乏特定治疗方法的病理状况。本综述总结了人类最常见的创伤性神经损伤的病理生理特征以及神经再生研究中使用的不同动物模型。然后描述了关于沃勒变性和神经再生的当前知识。最后，探讨了神经内血管生成在这些过程中的作用。由于对神经内血管生成的研究较少，我们对甘油注射损伤的大鼠坐骨神经进行了组织学实验。这些结果与文献数据一起表明，血管再生在周围神经再生中起重要作用，因此必须更仔细地进行研究。
