Frederiksen Marie, Thomsen Marianne, Vorkamp Katrin, Knudsen Lisbeth E
Institute of Public Health, University of Copenhagen, Øster Farimagsgade 5A, DK-1014 Copenhagen K, Denmark.
Chemosphere. 2009 Sep;76(11):1464-9. doi: 10.1016/j.chemosphere.2009.07.017. Epub 2009 Aug 13.
The levels and congener patterns of PBDEs were investigated in human placental samples in Denmark. The median concentrations of sigmaPBDE(tri-hepta) and BDE-209 in the 50 samples were 1.22 and 1.14 ng g(-1) lw, respectively, with the total sum ranging from 0.51 to 17.1 ng g(-1) lw, which is similar to previous placental studies. The PBDE content in placental tissue was dominated by BDE-209, which accounted for approximately 50% of the total amount of PBDEs. BDE-47, -99, and -153 were detected in all samples. Approximately equal amounts of BDE-47 and BDE-153 were observed in the placental tissue, which is in agreement with previous European studies of human serum. Principal Component Analysis (PCA) was performed to analyze congener patterns within and between mothers. The loading plot showed groupings of the measured PBDE variables in three groups, representative of Penta-, Octa- and Deca-BDE technical mixtures. Congeners representing the individual technical mixtures were close to orthogonal or inversely correlated, indicating variation in the congener patterns of internal exposure corresponding to the patterns of technical mixtures used in products. Visualisation of the participant objects according to body mass index (BMI), revealed inherent congener patterns (19% X-variance) showing increased frequency for participants within the highest BMI group to have elevated concentrations of BDE-209 in the placental tissue.
在丹麦的人体胎盘样本中对多溴二苯醚（PBDEs）的含量水平及同系物模式进行了研究。50个样本中，总多溴二苯醚（三至七溴）和BDE - 209的中位浓度分别为1.22和1.14纳克/克脂重，总量范围为0.51至17.1纳克/克脂重，这与之前的胎盘研究结果相似。胎盘组织中的多溴二苯醚含量以BDE - 209为主，约占多溴二苯醚总量的50%。所有样本中均检测到了BDE - 47、- 99和- 153。在胎盘组织中观察到BDE - 47和BDE - 153的含量大致相等，这与之前欧洲人体血清研究结果一致。进行了主成分分析（PCA）以分析母亲体内及母亲之间的同系物模式。载荷图显示，所测多溴二苯醚变量分为三组，分别代表五溴、八溴和十溴二苯醚商用混合物。代表各商用混合物的同系物接近正交或呈负相关，表明内暴露的同系物模式变化与产品中使用的商用混合物模式相对应。根据体重指数（BMI）对参与对象进行可视化分析，发现了内在的同系物模式（X方差为19%），显示BMI最高组的参与者胎盘组织中BDE - 209浓度升高的频率增加。
