七叶皂苷能改善精索静脉曲张相关不育症男性患者的精子质量。

Escin improves sperm quality in male patients with varicocele-associated infertility.

机构信息

Department of Internal Medicine, University of Missouri, Columbia, MO 65212, USA.

出版信息

Phytomedicine. 2010 Mar;17(3-4):192-6. doi: 10.1016/j.phymed.2009.07.014. Epub 2009 Aug 13.

DOI:10.1016/j.phymed.2009.07.014

PMID:19682880

Abstract

PURPOSE

To evaluate the efficacy of escin to improve sperm quality in Chinese male patients with varicocele-associated infertility.

METHODS

This study included 219 male patients with varicocele-associated infertility. These patients were randomly assigned into three groups: the control, the surgery and the escin group. 106 patients, with a mean age of 30 years old and a mean period of infertility of 5.0 years, were recruited in the escin group and a daily dose of 60mg (30mg every 12h) of escin was administered orally during an uninterrupted period of 2 months. The diameter of spermatic vein was also measured using color Doppler ultrasonography before and after treatment in the escin group. Patients in all groups took composite medicines favorable for sperm quality and semen were obtained and analyzed before and after treatment.

RESULTS

In response to treatment, the improvement rates in sperm density in the control, the surgery and the escin group, were 38.5%, 68.8%, and 57.5%, respectively. The differences in the surgery and the escin groups were significant compared to that in the control group (68.8% or 57.5% vs. 38.5%, P<0.05). The improvement rates in sperm motility in the control, the surgery and the escin group were 46.2%, 77.1%, and 55.7%, respectively. Significant difference was only observed between the surgery and the control group (77.1% vs. 46.2%, P<0.05). In the escin group, when severity of varicocele was classified to mild, moderate or severe degree according to the diameter of the spermatic vein, the improvement rates in disease severity were higher in the mild (41.7% vs. 20.0%, P<0.05) and moderate severity subgroups (64.4% vs. 20.0%, P<0.05) when compared to that in the severe subgroup (20.0%). The improvement rate in disease severity was also higher in the moderate subgroup when compared to that in the mild subgroup (64.4% vs. 41.7%, P<0.05). During the period of treatment, only very low frequencies of mild adverse effects were observed, most of which resolved without further symptomatic drug therapy after advising the patients to take escin after meal. Escin has little effect on vital signs, blood counts, liver or kidney function.

CONCLUSION

Escin is a safe and effective drug to improve sperm quality in Chinese male patients with varicocele-associated infertility.

摘要

目的

评估七叶皂苷改善精索静脉曲张相关不育中国男性患者精子质量的疗效。

方法

本研究纳入 219 例精索静脉曲张相关不育的男性患者。这些患者被随机分为三组：对照组、手术组和七叶皂苷组。七叶皂苷组共纳入 106 例患者，平均年龄 30 岁，平均不育时间为 5.0 年，给予七叶皂苷 60mg（每 12 小时 30mg）口服，连续治疗 2 个月。治疗前后采用彩色多普勒超声测量精索静脉直径。所有组患者均服用有利于精子质量的复合药物，并在治疗前后采集精液进行分析。

结果

治疗后，对照组、手术组和七叶皂苷组精子密度的改善率分别为 38.5%、68.8%和 57.5%。手术组和七叶皂苷组与对照组相比差异有统计学意义（68.8%或 57.5%比 38.5%，P<0.05）。对照组、手术组和七叶皂苷组精子活力的改善率分别为 46.2%、77.1%和 55.7%。仅手术组与对照组之间差异有统计学意义（77.1%比 46.2%，P<0.05）。在七叶皂苷组中，根据精索静脉直径将精索静脉曲张的严重程度分为轻度、中度和重度，轻度（41.7%比 20.0%，P<0.05）和中度（64.4%比 20.0%，P<0.05）严重程度亚组的疾病严重程度改善率高于重度亚组，中度严重程度亚组的疾病严重程度改善率也高于轻度亚组（64.4%比 41.7%，P<0.05）。治疗期间，仅观察到非常低频率的轻度不良反应，大多数患者在建议饭后服用七叶皂苷后无需进一步对症药物治疗即可缓解。七叶皂苷对生命体征、血细胞计数、肝肾功能无影响。