Department of Electrical and Computer Engineering, Purdue University, West Lafayette, Indiana 47907, USA.
J Am Soc Mass Spectrom. 2009 Nov;20(11):2144-53. doi: 10.1016/j.jasms.2009.06.019. Epub 2009 Jul 10.
The mass-selective manipulation of ions at elevated pressure, including mass analysis, ion isolation, or excitation, is of great interest for the development of mass spectrometry instrumentation, particularly for systems in which ion traps are employed as mass analyzers or storage devices. While experimental exploration of high-pressure mass analysis is limited by various difficulties, such as ion detection or electrical discharge at high-pressure, theoretical methods have been developed in this work to study ion/neutral collision effects within quadrupole ion traps and to explore their performance at pressures up to 1 Torr. Ion trapping, isolation, excitation, and resonance ejection were investigated over a wide pressure range. The theoretically calculated data were compared with available experimental data for pressures up to 50 mTorr, allowing the prediction of ion trap performance at pressures more than 10 times higher.
在高压下对离子进行有选择性的操控，包括质量分析、离子隔离或激发，这对于质谱仪器的发展非常重要，特别是对于那些采用离子阱作为质量分析器或存储设备的系统。虽然高压质量分析的实验探索受到各种困难的限制，例如在高压下离子检测或放电，但本工作中已经开发了理论方法来研究四极离子阱内的离子/中性碰撞效应，并探索其在高达 1 托的压力下的性能。研究了离子捕获、隔离、激发和共振喷射在很宽的压力范围内的情况。理论计算数据与高达 50 毫托的可用实验数据进行了比较，从而可以预测压力超过 10 倍的离子阱性能。
