Department of Radiation Oncology, Shandong Cancer Hospital & Institute, Jiyan Road 440, Jinan 250117, Shandong Province, China.
Lung Cancer. 2010 Jun;68(3):394-7. doi: 10.1016/j.lungcan.2009.07.009. Epub 2009 Aug 14.
The aim of the present study was to investigate the relationship between FDG uptake and clinical stage for non-small cell lung cancer. The patients who were histologically or cytologically proven to be adenocarcinoma (AC) or squamous cell carcinoma (SCC) lung cancer and conducted FDG PET/CT staging were retrospectively reviewed. The FDG uptake was quantified as the maximum standardized uptake value (SUVmax). And the T-N-M status was determined mainly by FDG PET-CT imaging according to the 1997 update of the international staging system for lung cancer. From December 2003 to November 2007, 266 cases (194 men and 72 women; age range 31-90 years, median 62 years) were analyzed, which included 161 AC and 105 SCC patients. The present study showed that both size (3.23+/-1.68cm vs 2.63+/-1.33cm, P=0.004) and SUVmax (9.82+/-5.08 vs 8.43+/-4.21, P=0.016) were significantly greater for SCC compared to AC. There was positive correlation between the SUVmax and size for both SCC and AC (r=0.651, 0.632, respectively; both P=0.000). Significant difference is found among different stages in SUVmax for AC (F=11.693, P=0.000) but not for SCC (F=1.514, P=0.216). After controlling the size factor, a significant correlation was found between tumor stage and FDG uptake value for AC (r=0.323, P=0.000), but not for SCC (r=0.113, P=0.252). In conclusion, this observation showed that tumor size and histologic subtype had influences upon FDG uptake in non-small cell lung cancer. It demonstrated significant correlation between clinical stage and SUVmax for AC, but not for SCC.
本研究旨在探讨非小细胞肺癌（NSCLC）的 FDG 摄取与临床分期之间的关系。回顾性分析了经组织学或细胞学证实为腺癌（AC）或鳞状细胞癌（SCC）肺癌并进行 FDG PET/CT 分期的患者。FDG 摄取量通过最大标准化摄取值（SUVmax）进行量化。T-N-M 分期主要根据 1997 年国际肺癌分期系统的更新，通过 FDG PET-CT 成像确定。2003 年 12 月至 2007 年 11 月，共分析了 266 例患者（194 例男性和 72 例女性；年龄 31-90 岁，中位数 62 岁），其中包括 161 例 AC 和 105 例 SCC 患者。本研究表明，SCC 的大小（3.23+/-1.68cm 比 2.63+/-1.33cm，P=0.004）和 SUVmax（9.82+/-5.08 比 8.43+/-4.21，P=0.016）均明显大于 AC。SCC 和 AC 的 SUVmax 与大小之间均存在正相关（r=0.651，0.632，均 P=0.000）。AC 的不同分期之间 SUVmax 存在显著差异（F=11.693，P=0.000），但 SCC 则没有（F=1.514，P=0.216）。在控制大小因素后，AC 的肿瘤分期与 FDG 摄取值之间存在显著相关性（r=0.323，P=0.000），但 SCC 则没有（r=0.113，P=0.252）。综上所述，该观察结果表明，肿瘤大小和组织学亚型对非小细胞肺癌的 FDG 摄取有影响。AC 的临床分期与 SUVmax 之间存在显著相关性，但 SCC 则没有。
